Exploring the Efficacy Evaluation Model for Androgenic Alopecia Using Hair Organoids: Transcending Conventional Hair Research

    April 2026 in “ Journal of Dermatological Science ”
    Seoyeon Kyung, Su Jin Lim, Kyung Eun Lee … Seunghyun Kang
    Studysummary This study highlights that hair-bearing organoids derived from embryonic stem cells can effectively model androgenic alopecia conditions and test the efficacy of anti-hair loss treatments.
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    Research cited in this study 16

    1. Effects of Oxytocin on the Hair Growth Ability of Dermal Papilla Cells Scientific Reports · 2023
    2. Applications of Human Pluripotent Stem Cell-Derived Skin Organoids in Dermatology ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Construction of Transcriptome Atlas of White Yak Hair Follicle During Anagen and Catagen Using Single-Cell RNA Sequencing BMC Genomics · 2022
    4. Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells Nature Protocols · 2022
    5. Two-Cell Assemblage Assay: A Simple In Vitro Method for Screening Hair Growth-Promoting Compounds Frontiers in Cell and Developmental Biology · 2020
    6. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    7. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    8. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    9. In Vivo and In Vitro Hair Growth Promotion Effects of Extract from Glycine Soja Siebold et Zucc Journal of Applied Biological Chemistry · 2016
    10. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    11. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    12. Stem Cell Markers (Cytokeratin 15, CD34, and Nestin) in Primary Scarring and Nonscarring Alopecia British Journal of Dermatology · 2009
    13. Proliferation, DNA Repair, and Apoptosis in Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2008
    14. Therapeutic Strategies for Treating Hair Loss Drug Discovery Today: Therapeutic Strategies · 2006
    15. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    16. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992