Dutasteride as an Effective Treatment in Androgenetic Alopecia: A Literature Review

Dutasteride, a dual 5α-reductase inhibitor, is more effective than finasteride in treating androgenetic alopecia (AGA) by significantly increasing hair count and shaft thickness, despite not being officially approved for AGA. It reduces serum dihydrotestosterone (DHT) levels by over 90%, offering broader inhibition than finasteride. Higher doses, like 2.5 mg, may enhance results, and mesotherapy could minimize systemic exposure, though more research is needed to confirm long-term safety and optimal dosing. Side effects are similar to finasteride, with concerns about long-term risks such as depression and metabolic changes. Mesotherapy might offer a safer delivery method, but more robust data are required for widespread use.