Role of ASLNC168501 in Regulating Hair Follicle Stem Cell Activity via the AR/miR-128-3p/IGF-1 Pathway

    January 2026 in “ Stem Cell Research & Therapy ”
    Xuewen Chen, Jingxiu Chai, Xuan Wang … Yuchong Chen
    Studysummary This study found that targeting the AR/miR-128-3p/IGF-1 pathway with ASLNC168501 shows potential for treating androgenetic alopecia by restoring hair follicle stem cell function and promoting hair regeneration.
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    Research cited in this study 17

    1. Mechanisms and Clinical Progress of Adipose-Derived Stem Cells and Their Derivatives in the Treatment of Hair Loss Stem Cell Research & Therapy · 2025
    2. Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia Acta Biomaterialia · 2025
    3. Exploring the Dermatological Applications of Human Mesenchymal Stem Cell Secretome: A Comprehensive Review Stem Cell Research & Therapy · 2025
    4. Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives Stem Cell Research & Therapy · 2025
    5. Hybrid Hair Follicle Stem Cell Extracellular Vesicles Co-Delivering Finasteride and Gold Nanoparticles for Androgenetic Alopecia Treatment Journal of Controlled Release · 2024
    6. Regenerative Medicine in the Treatment of Specific Dermatologic Disorders: A Systematic Review of Randomized Controlled Clinical Trials Stem cell research & therapy · 2024
    7. LncRNA RP11-818O24.3 Promotes Hair Follicle Recovery via FGF2-PI3K/Akt Signal Pathway Cytotechnology · 2024
    8. Short-Term Clinical Assessment of Treating Female Androgenic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles Biomedicines · 2024
    9. Optimization of Hair Follicle Spheroids for Hair-On-A-Chip Biomaterials Science · 2024
    10. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    11. The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
    12. 4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration Biomedicines · 2022
    13. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    14. Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells Frontiers in Genetics · 2022
    15. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    16. Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia Skin appendage disorders · 2017
    17. Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro British Journal of Dermatology · 2014