Androgens and hair: a biological paradox with clinical consequences
July 2012
in “Cambridge University Press eBooks”
TLDR Androgens can both increase body hair and cause scalp hair loss.
The document from 2012 explores the paradoxical effects of androgens on hair growth, where androgens can stimulate body hair development post-puberty but also cause scalp hair loss leading to baldness. It delves into the biology of hair follicles, their response to androgens, and the psychological impact of hair growth abnormalities. The document discusses the importance of androgen receptors and 5α-reductase in hair follicle response, with evidence suggesting that androgens act on dermal papilla cells to regulate hair characteristics. It also covers the clinical aspects of androgenetic alopecia (AGA), its genetic links, and the psychological effects of hair loss. Various treatments are mentioned, including antiandrogens for female hirsutism, 5α-reductase inhibitors like finasteride for male pattern baldness, and the potential of bimatoprost in clinical trials. The document underscores the need for ongoing research to better understand hair follicle biology and develop more effective treatments for hair disorders.
View this study on cambridge.org →
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