Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle
September 2005
in “
PLoS biology
”
mesenchymal dermal papilla cells epithelial stem cells hair follicle formation hair follicle growth transcriptional profiles molecular signatures DP niche hair disorders signaling regulators gene expression tissue biology disease DP cells stem cells hair growth gene profiles hair diseases signaling molecules gene activity tissue health
TLDR Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
The study investigated the molecular interactions between mesenchymal dermal papilla (DP) cells and epithelial stem cells in hair follicle formation and growth. Using a novel multicolor labeling approach with transgenic expression of fluorescent proteins and immunolabeling, researchers isolated pure populations of DP and surrounding cell types. They defined transcriptional profiles to develop molecular signatures characteristic of the DP niche, identifying genes linked to hair disorders and novel signaling regulators. These findings provided a foundation for future functional analyses of these genes in hair development and illustrated how understanding gene expression in complex niches can reveal insights into tissue biology and disease.
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