Developmental timing of hair follicle and dorsal skin innervation in mice
May 2002
in “Journal of comparative neurology”
TLDR Nerve growth in mouse skin and hair follicles happens in stages and is closely linked to hair development.
The study investigated the developmental timing of hair follicle and dorsal skin innervation in C57BL/6 mice using immunofluorescence and neuronal markers. It found that skin innervation occurred in successive waves, starting at embryonic day 15 (E15) before hair follicle development. By embryonic day 16 (E16), nerve fibers were associated with developing hair follicles, and by embryonic day 18 (E18), additional nerve fibers formed around the isthmus and bulge regions. At birth (P1), specific neuropeptides became detectable in nerve fibers, and by postnatal day 5 (P5), epidermal innervation peaked. This innervation decreased after hair shaft penetration (P7–P17). The study concluded that the sequence of innervation closely correlated with hair follicle development, indicating an interdependence between neuronal and epithelial morphogenesis.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Neural Mechanisms of Hair Growth Control
Nerves and chemicals in the body can affect hair growth and loss.
Related
research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes
Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
research A model system to analyse the ability of human keratinocytes to form hair follicles
Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
research Review of hair follicle dermal cells
Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
research STUDY ON HAIR FOLLICLE FORMATION INDUED BY DERAMAL PAPILLA CELL
Dermal papilla cells can help form hair follicles and produce hair.
research Trans‐species hair growth induction by human hair follicle dermal papillae
Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
research Role of hair papilla cells on induction and regeneration processes of hair follicles
Hair papilla cells can create and regenerate hair bulbs under the right conditions.