Androgen Receptor Copy Number Variation and Androgenetic Alopecia: A Case-Control Study

    April 2009 in “ PLOS ONE
    J Cobb, Stefan J. White, Stephen B. Harrap, Justine A. Ellis
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    TLDR No clear link between androgen receptor variation and hair loss, but more research needed.
    This document is a summary of four different studies that investigated the potential relationship between androgen receptor copy number variation (CNV) and androgenetic alopecia (AGA). The first study found no evidence of CNV in the AR gene in any of the cases or controls, suggesting no significant association between AGA and AR CNV. The second study also found no evidence of CNV in the regions of the AR that were examined. The third study found no evidence of AR CNV in DNA derived from lymphocytes, but could not rule out CNV around the AR in DNA contained in the cells of the hair follicles themselves. The fourth study found a significant association between AR gene CNV and AGA, suggesting that AR gene CNV may play a role in the development of AGA.
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