Adipose Tissue-Derived Exosomes in the Treatment of Lichen Planopilaris: A Case Report

September 2025 in “ Clinical Case Reports ”

Mohammad Ali Nilforoushzadeh, Ali Ezzatollahi Tanha, Soraya Talebi, Yekta Ghane, Niloufar Najar Nobari

adipose tissue-derived exosomes lichen planopilaris LPP hair preservation exosome therapy

TLDR Adipose tissue-derived exosomes may help treat lichen planopilaris and preserve hair.

This case report explores the use of adipose tissue-derived exosomes as a potential treatment for lichen planopilaris (LPP), particularly in cases where standard treatments have failed. The findings suggest that these exosomes may help in controlling symptoms and preserving hair, offering a promising new therapeutic avenue for LPP patients. While the report provides preliminary evidence, further research is needed to confirm the efficacy and safety of this approach.

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Research cited in this study

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Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells

research Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells

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HA-stimulated stem cell vesicles improved hair growth in male mice with androgenetic alopecia.

research Platelet-Rich Plasma as a New and Successful Treatment for Lichen Planopilaris: A Controlled Blinded Randomized Clinical Trial

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Platelet-rich plasma (PRP) is an effective treatment for lichen planopilaris.

research Autologous Adipose Tissue Injection in the Treatment of Alopecia: A Mini-Review

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research Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata

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Tiny particles from umbilical cord stem cells may help hair grow back in a type of hair loss.

research Reversible Hair Loss in Lichen Planopilaris: Regrowth With Low-Dose Naltrexone and Platelet-Rich Plasma

1 citations , May 2022 in “Journal of Drugs in Dermatology”

Low-dose naltrexone and platelet-rich plasma can regrow hair in lichen planopilaris.

research Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities

12 citations , April 2022 in “Journal of cosmetic dermatology”

Exosome therapy could help with hair loss, but more research is needed to confirm its safety and effectiveness.

research Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy

47 citations , December 2020 in “Journal of the European Academy of Dermatology and Venereology”

The document concludes that understanding and treating hair loss requires recognizing its various types and using appropriate diagnostic tools and treatments.

research Lichen Planopilaris: Retrospective Study on the Characteristics and Treatment of 291 Patients

48 citations , November 2018 in “Journal of dermatological treatment”

Women are more likely to have Lichen planopilaris, and treatments with cyclosporine and methotrexate are most effective but less safe than mycophenolate mofetil.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , April 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research Cicatricial Alopecia: Overview and Treatment Recommendations

23 citations , April 2018 in “Journal der Deutschen Dermatologischen Gesellschaft”

Permanent hair loss from cicatricial alopecia is treated by reducing inflammation and managing symptoms, but regrowth in scarred areas is unlikely.

research Lichen Planopilaris: Update on Diagnosis and Treatment

160 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”

New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.

research Lichen Planopilaris: Chronic Scarring Alopecia with Autoimmune Component

90 citations , July 2008 in “Dermatologic therapy”

Lichen planopilaris is a chronic, scarring hair loss condition with no definitive cure, requiring accurate diagnosis and treatment to manage symptoms.

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community My progress with various products and without oral fin or oral dut on 17 months

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The user shared their hair loss treatment progress using topical products like exosomes, fluridil, Kx826, and topical dutasteride, avoiding oral finasteride and dutasteride due to side effects. They found exosomes from Creative Biolabs most effective and also used topical probiotics, noting improvements without significant side effects.

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