A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity
December 2015
in “
The Journal of Cell Biology
”
Research cited in this study
14 / 14 results
research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions
Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function
Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.
research Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis
Human hair proteins vary by individual, body site, and ethnicity, useful for forensics.
research Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice
research Activation of Nrf2 in Keratinocytes Causes Chloracne-Like Skin Disease in Mice
Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.
research Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development
Mitochondrial reactive oxygen species are essential for skin and hair development.
research Keratin Function and Regulation in Tissue Homeostasis and Pathogenesis
Keratin is crucial for keeping skin cells healthy and its changes can lead to diseases and affect cell behavior.
research Proteomic Analysis of Hair Shaft and Nail Plate
Hair and nail proteins, mainly keratins, are crucial for structure and can indicate health issues.
research Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility
Epidermolysis bullosa simplex causes easily blistered skin due to faulty skin cell proteins, leading to new treatment ideas.
research Genetic Architecture of Mouse Skin Inflammation and Tumor Susceptibility
Lgr5 and the vitamin D receptor are key in controlling skin inflammation and tumor risk in mice.
research Animal Models of Human Skin Disease
Mutations in certain skin proteins cause severe skin issues, while others have limited effects, highlighting the need to understand these proteins for better treatments.
research Epidermal Differentiation: The Role of Proteases and Their Inhibitors
research Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin
Too much keratin 16 in mice skin causes abnormal skin thickening and structure.
Related Research
1 / 1 resultsresearch Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments
Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.