Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice May 2014 in “ Journal of Biological Chemistry ” David M. Alvarado, Pierre A. Coulombe We don't know much about this study yet. We're maintaining the world's largest resposity of hair loss research. You can help out the community by sending a PDF of this study here . Not sure how to get a study's PDF? You can email the authors of the study. View this study on jbc.org →
research Keratin Disorders: From Gene to Therapy 109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics” New treatments targeting specific genes show promise for treating keratin disorders.
research Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility 189 citations , July 2009 in “The Journal of clinical investigation/The journal of clinical investigation” Epidermolysis bullosa simplex causes easily blistered skin due to faulty skin cell proteins, leading to new treatment ideas.
research Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice 49 citations , August 2004 in “The FASEB Journal” Mice with human skin protein K8 had more skin problems and cancer.
research The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 53 citations , September 1999 in “The journal of cell biology/The Journal of cell biology” K16 can partially replace K14 but causes hair loss and skin issues.
research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development 318 citations , October 1998 in “The Journal of Cell Biology” Keratin 17 is important for skin development and may help define skin cell types.
research Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation 79 citations , August 1998 in “The Journal of Cell Biology” Keratin 16 delays skin maturation and affects skin and hair development in mice.
research Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin 94 citations , October 1994 in “The Journal of Cell Biology” Too much keratin 16 in mice skin causes abnormal skin thickening and structure.
research The Structure of Human Trichohyalin: Potential Multiple Roles as a Functional EF-Hand-Like Calcium-Binding Protein, a Cornified Cell Envelope Precursor, and an Intermediate Filament-Associated (Cross-Linking) Protein 161 citations , June 1993 in “Journal of Biological Chemistry” Trichohyalin helps in hair and skin cell structure and function by binding calcium and linking proteins.
research Keratin and Skin Disorders 28 citations , April 1996 in “Cell biology international” Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.