Stimuli-Responsive Hydrogels for Radiation-Induced Skin Injury: From Passive Barriers to Autonomous Drug Delivery Systems

    January 2026 in “ Regenerative Biomaterials ”
    Kai Zhang, Chulan Xiao, Yuanyuan Wang … Yi Li
    Studysummary This study highlights that hydrogel formulations unexpectedly prolonged healing in trials, pointing to a need for design based on detailed pathophysiological insights rather than empirical methods, and suggests technologies like AI materials optimization and 3D bioprinting to aid their clinical use for cancer survivors.
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    Research cited in this study 10

    1. Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights Biomimetics · 2025
    2. 3D Bioprinting of Prefabricated Artificial Skin with Multicomponent Hydrogel for Skin and Hair Follicle Regeneration Theranostics · 2025
    3. Ph-Responsive Hydrogel With Dual-Crosslinked Network of Polyvinyl Alcohol/Boric Acid for Controlled Release of Salvianolic Acid B: Novel Pro-Regenerative Mechanisms in Scar Inhibition and Wound Healing Regenerative Biomaterials · 2025
    4. Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review Gels · 2024
    5. Endogenous/Exogenous Stimuli-Responsive Smart Hydrogels for Diabetic Wound Healing Aggregate · 2024
    6. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024
    7. Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device Advanced healthcare materials/Advanced Healthcare Materials · 2024
    8. Hierarchically Assembled Nanofiber Scaffolds With Dual Growth Factor Gradients Promote Skin Wound Healing Through Rapid Cell Recruitment Advanced Science · 2024
    9. Hydrogel-Based Skin Regeneration International Journal of Molecular Sciences · 2024
    10. Single-Cell Transcriptomics Reveals a Senescence-Associated IL-6/CCR6 Axis Driving Radiodermatitis EMBO molecular medicine · 2022