Mathematical Model for Alopecia Areata

    June 2015 in “ Journal of theoretical biology ”
    A Dobréva, Ralf Paus, N. G. Cogan
    Studysummary This study suggests that immune privilege guardians and the pro-inflammatory cytokine interferon-γ significantly influence the dynamics of alopecia areata, supporting the hypothesis that immune privilege collapse is crucial in its development.
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    Research cited in this study 24

    1. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    2. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    3. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    4. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata Clinical and Developmental Immunology · 2013
    5. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
    6. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    7. Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level Indian Journal of Dermatology, Venereology and Leprology · 2012
    8. Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions Journal of Dermatological Science · 2010
    9. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    10. The Cycling Hair Follicle as an Ideal Systems Biology Research Model Experimental Dermatology · 2010
    11. Alopecia Areata Update Journal of the American Academy of Dermatology · 2010
    12. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    13. Neuroendocrinology of Epithelial Hair Follicle Stem Cells Molecular and Cellular Endocrinology · 2008
    14. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    15. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    16. Combination of Topical Garlic Gel and Betamethasone Valerate Cream in the Treatment of Localized Alopecia Areata: A Double-Blind Randomized Controlled Study Indian Journal of Dermatology Venereology and Leprology · 2007
    17. Alopecia Areata: Review and Update Anais Brasileiros de Dermatologia · 2005
    18. The Pathogenesis of Alopecia Areata in Rodent Models Journal of Investigative Dermatology Symposium Proceedings · 2003
    19. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    20. The Follicular Automaton Model: Effect of Stochasticity and Synchronization of Hair Cycles Journal of theoretical biology · 2002
    21. Shedding: How to Manage a Common Cause of Hair Loss Cleveland Clinic Journal of Medicine · 2001
    22. Modeling the Dynamics of Human Hair Cycles by a Follicular Automaton Proceedings of the National Academy of Sciences · 2000
    23. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    24. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998

    Related research 5

    1. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    2. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    4. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    5. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011