Synergistic Effects of Mesenchymal Stem Cells and Their Secretomes with Scaffolds in Burn Wound Healing: A Systematic Review and Meta-Analysis of Preclinical Studies

    July 2025 in “ Journal of Translational Medicine ”
    Amir Hossein Aghayan, Davood Mohammadi, Amir Atashi, Zahra Jamalpoor
    Studysummary In this study, MSC-scaffold combinations were found to significantly enhance wound closure, collagen deposition, angiogenesis, and growth factor expression while modulating inflammatory responses in preclinical burn wound models, though significant heterogeneity limits immediate clinical application.
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    Research cited in this study 10

    1. Advances in Regenerative Medicine-Based Approaches for Skin Regeneration and Rejuvenation Frontiers in Bioengineering and Biotechnology · 2025
    2. Exploring the Therapeutic Potential of Different Sources of Mesenchymal Stem Cells: A Novel Approach to Combat Burn Wound Infections Frontiers in Microbiology · 2024
    3. The Efficacy of Adipose-Derived Stem Cells in Burn Injuries: A Systematic Review Cellular & Molecular Biology Letters · 2024
    4. Mesenchymal Stem Cells Paracrine Proteins From Three-Dimensional Dynamic Culture System Promoted Wound Healing in Third-Degree Burn Models Bioengineering & translational medicine · 2023
    5. Stem Cell Therapy for Burns: The Story So Far Biologics · 2021
    6. 3D Bioprinting of Integral ADSCs-NO Hydrogel Scaffolds to Promote Severe Burn Wound Healing Regenerative Biomaterials · 2021
    7. Current Advanced Therapies Based on Human Mesenchymal Stem Cells for Skin Diseases Frontiers in Cell and Developmental Biology · 2021
    8. Efficacy Assessment of Mesenchymal Stem Cell Transplantation for Burn Wounds in Animals: A Systematic Review Stem Cell Research & Therapy · 2020
    9. Efficacy of Stem Cell Therapy for Burn Wounds: A Systematic Review and Meta-Analysis of Preclinical Studies Stem Cell Research & Therapy · 2020
    10. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine International Journal of Molecular Sciences · 2017