New Approach to the Understanding of Keloid: Psychoneuroimmune-Endocrine Aspects

February 2015 in “ Clinical Cosmetic and Investigational Dermatology ”

Felipe Contoli Isoldi, Bernardo Hochman, Fabianne Furtado, Lydia Masako Ferreira

keloid psychoneuroimmune endocrine psychological stress genetic predisposition environmental factors skin central nervous system stress-related hormones neuropeptides CRH IL-6 keloid pathogenesis stress–diathesis model corticotropin-releasing hormone interleukin-6

Studysummary This review explores the "brain-skin connection" and presents evidence suggesting keloids may be influenced by psychosocial stress, although it reports no new experimental results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis

51 citations , July 2010 in “Trends in Endocrinology and Metabolism”

This review discusses prolactin production and regulation in human skin and hair follicles, highlighting its potential broader implications but reports no new empirical results.

research Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ

64 citations , January 2010 in “The FASEB Journal”

This study found that prolactin is a key regulator of keratin expression in human hair follicles, enhancing specific keratin types and influencing epithelial stem cell-associated keratins.

research Melatonin in the Skin: Synthesis, Metabolism, and Functions

252 citations , January 2008 in “Trends in Endocrinology and Metabolism”

This review discusses the protective and stress-buffering roles of melatonin in skin functions and structures but does not present new clinical findings.

Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.

research Neuroimmunology of Stress: Skin Takes Center Stage

375 citations , July 2006 in “Journal of Investigative Dermatology”

This review discusses the brain-skin connection, the skin's role in stress response, and highlights unmet challenges in understanding stress-induced skin inflammation but reports no new experimental findings.

research Neuroimmunoendocrine Circuitry of the Brain-Skin Connection

293 citations , November 2005 in “Trends in Immunology”

This study indicates that stress in mice recruits specific neuroimmunoendocrine elements, leading to neurogenic skin inflammation that inhibits hair growth and highlights the skin's role in stress response research.

research Stress and Psychoneuroimmunologic Factors in Dermatology

34 citations , August 2005 in “Dermatologic Clinics”

This review discusses how the brain can influence skin biology, suggesting a link between psychological factors and skin health, but it reports no new scientific findings.

research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol

489 citations , June 2005 in “The FASEB Journal”

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations , August 2004 in “Journal of Investigative Dermatology”

This study suggests that stress negatively affects hair growth by inducing inflammation and early hair cycle transitions in mice, which might inform strategies for managing stress-related hair loss in humans.

Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

91 citations , May 2003 in “American Journal of Pathology”

This study found that prolactin and its receptor are expressed in the murine hair follicle epithelium, influencing hair cycle phases by down-regulating keratinocyte proliferation during anagen and inducing premature catagen.

research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin and Hair Growth Modulation by Neuropeptides

112 citations , February 2001 in “Journal of Investigative Dermatology”

This study found that substance P and calcitonin-gene-related peptide have different roles in regulating hair growth in mice, with substance P promoting anagen progression and calcitonin-gene-related peptide inhibiting it.