Progenitor-Cell-Enriched Micrografts as a Novel Option for the Management of Androgenetic Alopecia

October 2019 in “ Journal of Cellular Physiology ”

Rafael Ruiz, Jose M C Rosell, Gabriele Ceccarelli, Ciro De Sio, Gabriella De Angelis, Hernan Pinto, Carlo Astarita, Antonio Graziano

progenitor-cell-enriched micrografts androgenetic alopecia hair growth hair density hair follicles cuticle formation dermal papilla proliferation micrografts male pattern baldness hair loss hair thickness hair roots hair cuticle dermal papilla

Studysummary This study found that dermis micrografting improved hair growth and density in patients with androgenetic alopecia over 4, 6, and 12 months, suggesting it could be a novel treatment option.

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Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

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This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , April 2017 in “Journal of The American Academy of Dermatology”

This systematic review and meta-analysis found that minoxidil, finasteride, and low-level laser light therapy significantly improve hair growth in men with androgenetic alopecia, while minoxidil is also effective for women, compared to placebo.

research Platelet-Rich Plasma for Androgenetic Alopecia: Does It Work? Evidence from Meta-Analysis

64 citations , March 2017 in “Journal of Cosmetic Dermatology”

This meta-analysis suggests that local injection of platelet-rich plasma for androgenic alopecia is associated with an increased number of hairs and some increase in hair thickness, though larger studies are needed for confirmation.

research Body to Scalp: Evolving Trends in Body Hair Transplantation

22 citations , January 2017 in “Indian Dermatology Online Journal”

This review discusses the use of follicular unit extraction for hair restoration using body hair, reporting no new clinical findings, and highlights its potential for advanced baldness cases with limited scalp donor hair.

research Platelet-Rich Plasma in Androgenic Alopecia: Indications, Technique, and Potential Benefits

18 citations , November 2016 in “Journal of Oral and Maxillofacial Surgery”

This review discusses platelet-rich plasma for androgenic alopecia and reports beneficial effects on hair density and quality, but suggests more rigorous studies are needed for conclusive evidence.

research Regenerative Surgery in the Management of Leg Ulcers

15 citations , January 2016 in “Journal of cell science & therapy”

This study found that autologous micro-grafts improved wound healing and reduced pain in leg ulcers unresponsive to routine treatments within one week, lasting up to a month.

research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

70 citations , February 2015 in “Expert Opinion on Drug Discovery”

This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.

research Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

59 citations , May 2014 in “Expert Opinion on Therapeutic Targets”

This review discusses current therapeutic targets and treatments for androgenic alopecia but reports no clinical results; the authors highlight the challenge of developing multi-target drugs for effective treatment.

research Androgenetic Alopecia: An Evidence-Based Treatment Update

151 citations , May 2014 in “American Journal of Clinical Dermatology”

This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.

research Adipose Derived Stem Cells and Growth Factors Applied in Hair Transplantation: Follow-Up of Clinical Outcome

20 citations , January 2014 in “Journal of Cosmetics, Dermatological Sciences and Applications”

This study suggests that applying a suspension of adipose-derived cells during hair transplantation may enhance wound healing and promote continued hair growth shortly after the procedure.

Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

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research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

research Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication

41 citations , September 2010 in “Journal of dermatological science”

This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hair follicles in mice, indicating potential for developing hair cell therapy using stem cells.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations , January 2010 in “Biomedical research”

This study found that subcutaneous administration of conditioned medium from adipose-derived stem cells promoted hair growth in mice, and hypoxia enhanced this effect by altering growth factor secretion.

research Use of the TrichoScan to Assess Female Pattern Hair Loss

30 citations , April 2009 in “Dermatologic Surgery”

This study found that miniaturization of hair is present in some women with androgenetic alopecia, but diagnosis may also be based on differences in hair shaft diameter between scalp regions.

The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

research The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

47 citations , September 2008 in “British Journal of Dermatology”

This study found that women with androgenetic alopecia experience diffuse hair loss due to a decrease in terminal hairs and an increase in vellus hairs per follicular unit.

research Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice

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This study found that when human hair follicles were grafted onto mice, they progressed through dystrophic stages and returned to normal growth, with stem cells aiding in recovery.