Kaempferol Stimulates Dermal Papilla Cells and Upregulates Wnt/β-Catenin Signaling Pathway for Androgenetic Alopecia Treatment

    Changjiang Zhao, Ling-ling Jia, Ruiyu Luo … Yufei Li
    Studysummary This study found that kaempferol may stimulate hair growth in androgenetic alopecia by enhancing dermal papilla cell function and reducing dihydrotestosterone-induced damage, showing comparable efficacy to finasteride in a mouse model.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 19

    1. Antioxidant Properties of Platycladus Orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair Molecules/Molecules online/Molecules annual · 2024
    2. Chemical Constituents of Halophyte Suaeda Glauca and Their Therapeutic Potential for Hair Loss Molecules/Molecules online/Molecules annual · 2024
    3. Natural Compounds Used For Treating Hair Loss Current Pharmaceutical Design · 2023
    4. Curcumin-Zinc Framework Encapsulated Microneedle Patch for Promoting Hair Growth Theranostics · 2023
    5. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    6. Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking Clinical, Cosmetic and Investigational Dermatology · 2022
    7. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    8. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    9. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    10. Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review International Journal of Molecular Sciences · 2020
    11. Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules International Journal of Molecular Sciences · 2019
    12. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    13. Androgenetic Alopecia: A Review Endocrine · 2017
    14. Stimulatory Effect of Brazilian Propolis on Hair Growth Through Proliferation of Keratinocytes in Mice Journal of Agricultural and Food Chemistry · 2014
    15. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2013
    16. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    17. 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment Journal of Ethnopharmacology · 2011
    18. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    19. Treatment of Hair Loss The New England Journal of Medicine · 1999