Kaempferol Enhances Hair Growth by Regulating JAK3/STAT6 and TGF-β/Smad Signaling in Human Dermal Papilla Cells and a C57BL/6 Mouse Model

October 2025 in “ Records of Natural Products ”

Bu Young Choi

kaempferol JAK3/STAT6 TGF-β/Smad human dermal papilla cells C57BL/6 mouse model minoxidil TGF-β1 Smad-binding activity IL-4 STAT6 finasteride tofacitinib phosphorylated Smad2/3 CDK2 CDK4 cyclin D3 ERK1/2 IGF-1R VEGFR-2 Rogaine Propecia

Studysummary This research found that kaempferol, a flavonoid from hair growth-promoting plants, significantly enhanced human dermal papilla cell proliferation and inhibited specific signaling pathways, outperforming minoxidil, with topical application in mice promoting hair growth and thickness, indicating potential as a natural hair loss treatment.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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