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research Kaempferol enhances hair growth by regulating JAK3/STAT6 and TGF-β/Smad signaling in human dermal papilla cells and a C57BL/6 mousemodel

October 2025 in “Records of Natural Products”

This research found that kaempferol, a flavonoid from hair growth-promoting plants, significantly enhanced human dermal papilla cell proliferation and inhibited specific signaling pathways, outperforming minoxidil, with topical application in mice promoting hair growth and thickness, indicating potential as a natural hair loss treatment.

research Lagerstroemia indica extract regulates human hair dermal papilla cell growth and degeneration via modulation of β‐catenin, Stat6, and TGF‐β signaling pathway

6 citations , May 2022 in “Journal of Cosmetic Dermatology”

In this study, Lagerstroemia indica extract was found to significantly promote hair growth and prevent hair loss in human trials, likely through the regulation of specific signaling pathways, indicating its potential as a cosmetic treatment for hair loss prevention.

research Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata

November 2025 in “Scholarly Commons (Embry–Riddle Aeronautical University)”

This review discusses how urban air pollutants may influence the regulation of JAK3 signaling in alopecia areata and reports no new experimental results; the authors integrate existing data to map potential pathways and biomarkers.

research JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis

223 citations , September 2018 in “Rheumatology”

This review examines clinical data on the efficacy and safety of JAK inhibitors used for immune-mediated conditions beyond rheumatoid arthritis, highlighting their potential therapeutic roles in various inflammatory diseases.