The Potential Involvement of Cholinergic System in Finasteride Induced Cognitive Dysfunction

    November 2020 in “ Psychoneuroendocrinology ”
    Ashutosh Ahire, Kala P. Nair, B.S. Shankaranarayana Rao, B.N. Srikumar
    Studysummary In this study, repeated finasteride administration was associated with decreased social interaction and cognitive deficits in male rats, potentially linked to changes in cholinergic system activity.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 26

    1. Inhibition of 5α-Reductase Impairs Cognitive Performance, Alters Dendritic Morphology, and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice Neuroscience · 2020
    2. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    3. Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats Behavioural Brain Research · 2019
    4. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    5. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome Urology · 2018
    6. The Risk of Dementia with the Use of 5 Alpha Reductase Inhibitors Journal of the neurological sciences · 2017
    7. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    8. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    9. Sex and Estrous Cycle Influence Diazepam Effects on Anxiety and Memory: Possible Role of Progesterone Progress in Neuro-Psychopharmacology and Biological Psychiatry · 2016
    10. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    11. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016
    12. Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats PLOS ONE · 2015
    13. Cognitive Effects of Testosterone and Finasteride Administration in Older Hypogonadal Men PubMed · 2014
    14. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    15. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    16. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    17. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    18. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    19. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    20. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    21. Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone International Journal of Andrology · 2007
    22. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    23. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    24. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    25. Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and Its Clinical Significance: A Prospective Clinical Study Steroids · 1998
    26. Reversible Decreases of Fertility in Male Sprague-Dawley Rats Treated Orally with Finasteride, a 5α-Reductase Inhibitor Reproductive Toxicology · 1991