Cognitive Dysfunction Following Finasteride Use: A Disproportionality Analysis of the Global Pharmacovigilance Database

    December 2023 in “ Expert Opinion on Drug Safety ”
    Yongtai Cho, Sungho Bea, Ji-Hwan Bae … Ju Young Shin
    Studysummary This abstract raises concerns about the safety of finasteride, a medication often used for treating hair loss and prostate issues, due to emerging reports linking it to cognitive dysfunction.
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    Research cited in this study 19

    1. Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide JAMA network open · 2022
    2. Case Report: A Study of the Clinical Characteristics and Genetic Variants of Post-Finasteride Syndrome Patients Translational Andrology and Urology · 2022
    3. Disproportional Signal of Sexual Dysfunction Reports Associated with Finasteride Use in Young Men with Androgenetic Alopecia: A Pharmacovigilance Analysis of VigiBase Journal of The American Academy of Dermatology · 2022
    4. Post-Finasteride Syndrome: Literature Review Archivos españoles de urología · 2022
    5. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    6. Post-Finasteride Syndrome BMJ · 2019
    7. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome Urology · 2018
    8. Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men American Journal of Men's Health · 2018
    9. The Risk of Dementia with the Use of 5 Alpha Reductase Inhibitors Journal of the neurological sciences · 2017
    10. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    11. Androgenetic Alopecia: A Review Endocrine · 2017
    12. Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
    13. Finasteride Adverse Effects in Subjects with Androgenic Alopecia: A Possible Therapeutic Approach According to the Lateralization Process of the Brain Journal of Dermatological Treatment · 2016
    14. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    15. Cognitive Effects of Testosterone and Finasteride Administration in Older Hypogonadal Men PubMed · 2014
    16. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    17. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    18. Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone International Journal of Andrology · 2007
    19. Effects of Finasteride on Vascular Endothelial Growth Factor Scandinavian Journal of Urology and Nephrology · 2002

    Related research 6

    1. Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year Journal of The American Academy of Dermatology · 2020
    2. A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits Journal of Drug Delivery and Therapeutics · 2019
    3. Clinical Observation on Acne Patients Taking Finasteride China Medical Abstract of Dermatology · 2013
    4. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    5. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    6. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995