34 citations
,
January 1995 in “The Journal of Clinical Endocrinology and Metabolism” 20 citations
,
December 1994 in “Fertility and sterility” In this study, treatment with flutamide combined with a low-dose oral contraceptive significantly improved hirsutism in women with polycystic ovarian disease who did not respond to oral contraceptive treatment alone.
165 citations
,
February 1994 in “Fertility and Sterility” This study found that flutamide was more effective than spironolactone in reducing symptoms of hirsutism and related conditions in premenopausal women, with fewer discontinuations due to side effects.
187 citations
,
January 1994 in “The New England Journal of Medicine” Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.
43 citations
,
December 1993 in “Annals of internal medicine” This letter discusses the first reported case of serious liver damage linked to the use of flutamide for hirsutism in a woman, highlighting a potential risk for hepatotoxicity with this treatment.
34 citations
,
February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.
1040 citations
,
October 1992 in “The New England Journal of Medicine” In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.
116 citations
,
May 1992 in “The American Journal of Medicine” This study found that flutamide-induced liver toxicity in prostate cancer patients was very rare, occurring in only 0.18% of cases with clinical manifestations, and symptoms resolved after discontinuing the drug.
40 citations
,
February 1992 in “The Journal of Clinical Endocrinology and Metabolism” Taking finasteride pills and using minoxidil lotion together can help grow hair.
27 citations
,
October 1991 in “International journal of gynaecology and obstetrics” This study observed that flutamide treatment reduced hair growth and improved acne and seborrhea in hirsute women, with increased androstenedione levels and no side effects noted.
68 citations
,
May 1991 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that both cyproterone acetate and spironolactone effectively reduced hair diameter and plasma testosterone levels in hirsute women, with no significant differences between the two treatments.
130 citations
,
September 1990 in “Journal of the American Academy of Dermatology” This study found that combining flutamide with an oral contraceptive significantly reduced hirsutism, acne, and seborrhea in patients after seven months, without significant side effects.
25 citations
,
August 1989 in “Seminars in reproductive medicine” This article discusses the use of oral contraceptives for treating hyperandrogenism in women, reporting improvement in most patients, especially in reducing new hair growth, but presents no new clinical findings.
23 citations
,
July 1989 in “Postgraduate medical journal” This study found that spironolactone 100 mg daily did not demonstrate objective benefits in managing idiopathic hirsutism, as it increased hair shaft diameter without reducing serum androgen levels.
17 citations
,
February 1989 in “Fertility and sterility” In this study, cimetidine at a daily dose of 1.5 gm for 3 months did not significantly affect hair growth in women with moderate to severe hirsutism.
96 citations
,
October 1987 in “The Journal of Clinical Endocrinology & Metabolism” This study found that long-term GnRH agonist administration in premenopausal women with polycystic ovarian disease resulted in persistent suppression of ovarian steroid secretion, while adrenal steroid levels remained unchanged.
64 citations
,
January 1985 in “Clinical endocrinology” In this study, treatment with the oral contraceptive containing 30 μg ethinyl oestradiol and 150 μg desogestrel significantly reduced androgen-dependent hair growth in hirsute women over one year.
53 citations
,
January 1985 in “Acta obstetricia et gynecologica Scandinavica” This study found that an 8-month treatment with a low-dose oral contraceptive significantly reduced testosterone levels and hair growth in women with polycystic ovary syndrome and hirsutism, with minimal side effects.
101 citations
,
January 1985 in “British Journal of Dermatology” This article discusses oral spironolactone therapy for female patients with acne, hirsutism, or androgenic alopecia and reports no new clinical results.
232 citations
,
June 1975 in “Journal of Steroid Biochemistry” In this study, a treatment regimen combining cyproterone acetate and ethinyl estradiol significantly improved acne and seborrhoea in most women after three months, but had varied effects on hirsutism and alopecia.
