Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology

    Ewan A. Langan
    Studysummary In this review, the potential role of the hormone prolactin in skin biology and its implications for treating skin diseases and hair disorders are explored, with a focus on its stress-related impacts and possible immunomodulatory function in the context of COVID-19.
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    Research cited in this study 26

    1. Parkinson's Disease and Skin Disorders: Non-Iatrogenic and Iatrogenic Connections Parkinsonism & related disorders (Online)/Parkinsonism & related disorders · 2021
    2. Alopecia in Preexisting Autoimmune Thyroid Disease in Family Medicine Practice: Can Hyperprolactinemia Induce Hair Loss? A Case Report Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2021
    3. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee The Journal of Clinical Endocrinology and Metabolism · 2019
    4. JAK Inhibitors and Alopecia Areata Lancet · 2019
    5. Prolactin as a Candidate Sebotropic Hormone? Experimental Dermatology · 2018
    6. Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ Clinics in dermatology · 2016
    7. Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013
    8. Utilizing the Hair Follicle to Dissect the Regulation and Autocrine/Paracrine Activities of Prolactin in Humans Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism · 2012
    9. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    10. Hair Loss and Hyperprolactinemia in Women Dermato-endocrinology · 2012
    11. Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis Trends in Endocrinology and Metabolism · 2010
    12. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    13. Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro British Journal of Dermatology · 2010
    14. Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ The FASEB Journal · 2010
    15. Mind the Gender Gap: Does Prolactin Exert Gender and Site-Specific Effects on the Human Hair Follicle? Journal of Investigative Dermatology · 2009
    16. Neuroendocrine Perspectives in Alopecia Areata: Does Stress Play a Role? Journal of Investigative Dermatology · 2009
    17. Seasonality of Hair Shedding in Healthy Women Complaining of Hair Loss Dermatology · 2009
    18. Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone Journal of Investigative Dermatology · 2008
    19. Prolactin Delays Hair Regrowth in Mice Journal of Endocrinology · 2006
    20. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006
    21. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    22. Effect of Constant-Release Melatonin Implants and Prolonged Exposure to a Long Day Photoperiod on Prolactin Secretion and Hair Growth in Mouflon (Ovis Gmelini Musimon) Domestic animal endocrinology · 2004
    23. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003
    24. Acne American journal of clinical dermatology · 2002
    25. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001
    26. Does Prolactin Play a Role in Skin Biology and Pathology? Medical hypotheses · 1991