Stem Cell-Based Strategies for Skin Regeneration and Repair: Current Approaches, Preclinical, and Clinical Evidence

July 2026 in “ Current Stem Cell Reports ”

Keerthiraj Kalmantidoddi Shivaji, Balamuralidhara Veeranna, Soundarya Raju, B. K. Rajkumar, Sagar Guruswamy

stem cell-based therapies skin regeneration mesenchymal stem cells hair follicle stem cells angiogenesis immunomodulation diabetic ulcers alopecia biomaterials tissue engineering stem cell therapy hair loss wound healing

Studysummary This review highlights that stem cell-based therapies show promise in skin regeneration for conditions like chronic wounds and burns due to their regenerative and immunomodulatory effects, though challenges like safety and scalability limit widespread clinical use.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

21 / 21 results

research Bioengineering Strategies for Regeneration of Skin Integrity: A Literature Review

December 2024 in “Regenerative Therapy”

This study review found that stem cells can be transformed into normal skin cells and skin organoids, offering promising methods for regenerating skin integrity and advancing both basic and clinical skin biology research.

research In Vitro Differentiation of Hair-Follicle Bulge Stem Cells Into Synaptophysin-Expressing Neurons: A Potential New Approach for Neuro-Regeneration

November 2024 in “Human Cell”

This study found that treating rat whisker follicle stem cells with retinoic acid and epidermal growth factor induced them to express synaptophysin, a marker of mature neurons, although there was a reduction in other neural markers, suggesting potential for neuro-regeneration applications.

research Organoids in Skin Wound Healing

November 2024 in “Burns & Trauma”

This review examines how skin organoids, derived from stem cells, are constructed to simulate skin functions and are pivotal in wound healing and regeneration, highlighting their promising roles in both research and therapeutic applications.

research Stem Cell Activity-Coupled Suppression of Endogenous Retrovirus Governs Adult Tissue Regeneration

12 citations , October 2024 in “Cell”

research Epidermal Stem Cells: Skin Surveillance And Clinical Perspective

19 citations , August 2024 in “Journal of Translational Medicine”

This review explores recent advancements in understanding how various physiological and psychological factors, such as stress and aging, influence epidermal stem cell populations, highlighting their importance in immune-related skin disorders and potential for clinical applications.

research Stem-Cell Therapy in Dermatology: Challenges and Opportunities

August 2024 in “Indian Journal of Skin Allergy”

This review outlines the current state of stem cell therapy in dermatology, highlighting its potential for treating a variety of skin disorders and conditions, while emphasizing the need for further controlled studies to standardize treatment and fully understand its efficacy and limitations.

research Role of Umbilical Cord Mesenchymal Stromal Cells in Skin Rejuvenation

10 citations , May 2024 in “npj Regenerative Medicine”

This review discusses the role of umbilical cord-derived mesenchymal stromal cells in skin rejuvenation and reports no new clinical results; it emphasizes their potential in delaying skin aging.

research Skin Pigmentation Types, Causes and Treatment: A Review

138 citations , June 2023 in “Molecules”

This review examines various skin pigmentation disorders, their causes, and potential treatments, detailing 25 plants, 4 marine species, and 17 clinically tested topical and oral medications for managing these conditions.

research Application of Stem Cells in Regenerative Medicine

3 citations , June 2023 in “MedComm”

This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.

research Stem Cell Applications in Human Hair Growth: A Literature Review

8 citations , April 2023 in “Cureus”

This review explores stem cell applications for hair regrowth in alopecia, with no new clinical results, suggesting potential advantages over current FDA-approved treatments.

research Single-Stage Transplantation with Epidermal Stem Cells Enhances Survival of Tissue-Engineered Skin by Inducing Early Angiogenesis

11 citations , March 2023 in “Stem Cell Research & Therapy”

In this study, epidermal stem cells were found to enhance blood vessel formation and support successful one-step transplantation of tissue-engineered skin in a rat model.

research Alpinetin Promotes Hair Regeneration via Activating Hair Follicle Stem Cells

11 citations , May 2022 in “Chinese medicine”

This study found that Alpinetin, applied topically in C57BL/6J mice, promoted hair regeneration by activating hair follicle stem cells through Wnt signaling, extending the anagen phase and increasing hair shaft length, with no cytotoxicity observed in keratinocytes and fibroblasts.

Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

11 citations , October 2021 in “Stem Cell Research & Therapy”

This study reports that hair follicle-derived mesenchymal stem cells significantly reduced hair loss and inflammation in alopecia areata models, suggesting a potential therapeutic approach.

research Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway

13 citations , August 2021 in “Frontiers in Bioengineering and Biotechnology”

This study found that adipose-derived exosomes may inhibit adipogenesis and lipogenesis in adipose-derived stem cells by activating Hedgehog signaling, suggesting potential applications for improving wound healing in obesity.

research Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation

76 citations , February 2021 in “International Journal of Molecular Sciences”

This review examines how mesenchymal stem cells and their derivatives may enhance skin regeneration and rejuvenation, but it reports no new clinical results; the authors suggest iPSC-derived MSCs hold promise for future therapies.

research Combination of Lyophilized Adipose-Derived Stem Cell Concentrated Conditioned Medium and Polysaccharide Hydrogel in the Inhibition of Hypertrophic Scarring

45 citations , January 2021 in “Stem Cell Research & Therapy”

This study found that incorporating adipose-derived stem cell conditioned medium into a polysaccharide hydrogel effectively reduced scar hyperplasia, with the combination offering better outcomes in preventing hypertrophic scarring compared to the medium alone in a rabbit ear model.

research The Dynamics of the Skin’s Immune System

306 citations , April 2019 in “International Journal of Molecular Sciences”

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

research Tissue Engineering of Skin and Regenerative Medicine for Wound Care

192 citations , January 2018 in “Burns & Trauma”

This review discusses the advancements in biologic skin substitutes for wound treatment and their potential in enhancing cutaneous regeneration but reports no new clinical results.

research Advances in Hair Restoration

17 citations , November 2017 in “Dermatologic Clinics”

This article discusses advancements in hair restoration, highlighting the use of robotics and follicular unit extraction along with adjuvant therapies like platelet-rich plasma, but presents no new clinical findings.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations , June 2017 in “Stem cell investigation”

This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.

A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice

research A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice

36 citations , January 2017 in “Stem Cells International”

This study found that Wnt7a-containing conditioned medium from UC-MSCs can accelerate wound healing and promote hair follicle regeneration by enhancing specific cellular functions in the wound microenvironment.