Engineering Immunomodulatory Biomaterials to Drive Skin Wounds Toward Regenerative Healing

    September 2022 in “ Cold Spring Harbor Perspectives in Biology ”
    Sergei Butenko, Hiromi Miwa, Yingzi Liu … Wendy F. Liu
    Studysummary This review discusses the immune system's role in skin repair and regeneration, highlighting how biomaterials could potentially enhance fully functional skin regeneration through immunomodulatory mechanisms, but reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on pmc.ncbi.nlm.nih.gov →
    Discuss this study in the Community →

    Research cited in this study 16

    1. ACKR2 Limits Skin Fibrosis and Hair Loss Through IFN-β The FASEB Journal · 2021
    2. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    3. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    4. Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing Nature Materials · 2020
    5. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020
    6. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    7. Choreographing Immunity in the Skin Epithelial Barrier Immunity · 2019
    8. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    9. M2 Macrophages Promote Wound-Induced Hair Neogenesis Journal of Dermatological Science · 2018
    10. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    11. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    12. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    13. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    14. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    15. Dextran Hydrogel Scaffolds Enhance Angiogenic Responses and Promote Complete Skin Regeneration During Burn Wound Healing Proceedings of the National Academy of Sciences · 2011
    16. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007