Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells

    October 2017 in “ Stem Cell Reports ”
    Chih‐Li Lin, Ruijuan Xu, Jae Kyo Yi … Cungui Mao
    Studysummary This study found that loss of the ACER1 gene in mice led to increased ceramide levels and progressive hair loss, highlighting ACER1's role in maintaining hair follicle stem cell homeostasis.
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    Research cited in this study 12

    1. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    2. Alkaline Ceramidase 1 Is Essential for Mammalian Skin Homeostasis and Regulating Whole-Body Energy Expenditure The Journal of Pathology · 2016
    3. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    4. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    5. Ceramide Synthase 4 Deficiency in Mice Causes Lipid Alterations in Sebum and Results in Alopecia Biochemical Journal · 2014
    6. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    7. Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    8. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    9. Development and Homeostasis of the Skin Epidermis Cold Spring Harbor perspectives in biology · 2012
    10. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    11. Scratching the Surface of Skin Development Nature · 2007
    12. The Hair Cycle Journal of Cell Science · 2006