A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia

    March 2025 in “ Life ”
    Farahnaz Amini, Jun Liang Teh, Chung Keat Tan … Edmond Siah Chye Ng
    Studysummary This study found that an exosome formulation with plant extracts significantly increased hair regrowth in men with male pattern alopecia compared to a placebo, without notable adverse effects.
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    Research cited in this study 21

    1. Hair Repigmentation of Poliosis Circumscripta in Androgenetic Alopecia Patient Treated With Exosomes and Fractional Picosecond Laser Journal of Cosmetic Dermatology · 2024
    2. Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata Cell Biology International · 2023
    3. Combination of Adipose-Derived Stem Cell Conditioned Media and Minoxidil for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-Blind Clinical Trial Stem Cell Research & Therapy · 2023
    4. Systematic Review of Exosome Treatment in Hair Restoration: Preliminary Evidence, Safety, and Future Directions Journal of Cosmetic Dermatology · 2023
    5. Platelet-Rich Plasma for Treatment of Hair Loss Improves Patient-Reported Quality of Life Aesthetic Plastic Surgery · 2023
    6. Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing Frontiers in Medicine · 2022
    7. Modulation of Hair Growth Promoting Effect by Natural Products Pharmaceutics · 2021
    8. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    9. Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration Tissue Engineering and Regenerative Medicine · 2021
    10. Exploring the Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021
    11. Dermal Macrophage and Its Potential in Inducing Hair Follicle Regeneration Molecular Immunology · 2021
    12. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    13. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cells Tissue Engineering and Regenerative Medicine · 2020
    14. Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres Experimental Dermatology · 2019
    15. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    16. Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells Current stem cell research & therapy · 2017
    17. Enhancement of Human Hair Growth Using Ecklonia Cava Polyphenols Annals of Dermatology · 2016
    18. Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis BMC Complementary and Alternative Medicine · 2013
    19. The Latest Advance in Hair Regeneration Therapy Using Proteins Secreted by Adipose-Derived Stem Cells The American Journal of Cosmetic Surgery · 2012
    20. Effect of Dieckol, a Component of Ecklonia Cava, on the Promotion of Hair Growth International Journal of Molecular Sciences · 2012
    21. Interventions for Alopecia Areata Cochrane library · 2008