Diet and Hair Loss: Effects of Nutrient Deficiency and Supplement Use

This study found that arachidonic acid may promote hair growth by enhancing dermal papilla cell function and stimulating the anagen phase in C57BL/6 mice.

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

This study found that a 6-month supplementation with omega 3, omega 6, and antioxidants significantly improved hair density and reduced hair loss in women with female pattern hair loss.

This study found that a marine-extract dietary supplement significantly reduced hair shedding and increased hair diameter in premenopausal women with subclinical hair thinning or hair loss after 6 months of use.

This study found that an oral marine protein supplement significantly increased hair growth and reduced hair shedding in women with temporary thinning hair over 90 days compared to a placebo.

This study found that feeding mice high levels of dietary vitamin A increased WNT signaling, which activated hair follicle stem cells and may have accelerated alopecia areata progression.

This article discusses the history taking and clinical examination process for diagnosing alopecia and outlines a diagnostic approach, noting that it reports no new clinical results.

This study found that low serum ferritin and vitamin D2 levels are associated with hair loss in females with chronic telogen effluvium and female pattern hair loss, suggesting potential benefits of screening and supplementation.

This study observed that patients with various types of hair loss had significantly lower serum zinc levels compared to healthy controls, suggesting zinc disturbance may play a role in the condition.

This article reviews the impact of nutritional deficiencies on hair health, detailing how they can cause structural abnormalities, pigmentation changes, or hair loss; it presents no new clinical findings.

In this study, all five patients with zinc deficiency-related hair loss experienced improvement or recovery of their condition after receiving oral zinc treatment.

This study describes a case series of nine patients experiencing symptoms of selenium toxicity after consuming a liquid dietary supplement with an excess amount of selenium.

This review examines the role of retinoic acid synthesis in hair follicles and sebaceous glands, focusing on its localization and function during normal and disease states, but reports no new results.

This study demonstrated that tocotrienol supplementation increased hair number in individuals with hair loss compared to a placebo, likely due to its antioxidant effects.

This study concluded that iron deficiency is common among women but not more prevalent in those with female pattern hair loss or chronic telogen effluvium compared to control subjects without hair loss.

This review examines the debated link between iron deficiency and nonscarring scalp alopecia in women, offering no new clinical results but emphasizing the need for further research and well-designed trials.

In this mouse study, severe selenoprotein deficiency in epidermal cells was linked to skin abnormalities, disrupted hair follicle development, and progressive alopecia, highlighting the role of selenoproteins in skin and hair health.

This review discusses how changes in hair and skin may indicate underlying vitamin deficiencies and emphasizes the need to identify populations at risk for these deficiencies; it reports no new results.

Excessive selenium in supplements can cause hair loss and nail issues.

This article outlines the potential for upregulating the vitamin D receptor in treating hair disorders, emphasizing the need for further studies to evaluate vitamin D's role in the hair cycle.

This review discusses studies on hair growth and protein synthesis in hair follicles, highlighting the differing responses of mohair and cashmere goat follicles to signaling molecules, biotin, and amino acids, but contains no new results.

This study observed that psychological factors and serum levels of zinc, folate, and vitamin B12 may contribute to the development of trichodynia.

In this study, oral zinc supplementation for twelve weeks increased serum zinc levels in alopecia areata patients with low zinc, showing positive hair regrowth in 66.7% of participants, though this was not statistically significant.

This study found that pediatric patients on valproic acid may experience hair loss due to reduced zinc and biotinidase levels within the first 3 months, with zinc depletion continuing to contribute by the 6th month.

This review discusses the various treatment options for male and female pattern hair loss and provides no new clinical results; the authors outline the most effective strategies based on existing evidence.

This study observed that vitamin D receptor expression in certain hair follicle cells varies throughout the murine hair cycle, suggesting a potential role for 1,25-dihydroxyvitamin D3 in hair follicle biology.

This review discusses the complexities of diagnosing and treating iron deficiency related to nutritional anemia and hair loss, concluding that routine screening and supplementation for hair loss are not yet supported by sufficient evidence.

This study found that bulge cells marked by CD200+ in human hair follicles show high colony-forming efficiency, suggesting successful enrichment of keratinocyte stem cells.

This case report describes a 5-month-old Japanese infant with biotin deficiency, where daily oral biotin supplementation led to significant improvements in skin conditions and hair growth.

This study found that women with androgenetic alopecia or alopecia areata have significantly lower serum ferritin levels than those without hair loss, suggesting a potential link between these types of alopecia and decreased iron stores.

This study found no direct relationship between low serum ferritin and chronic diffuse telogen hair loss in women, questioning the usefulness of serum ferritin measurement and iron supplementation for managing this condition.

This review explores the role of nutritional factors in hair loss, noting that iron and l-lysine supplementation may benefit some individuals, while excessive supplements can lead to hair shedding.

This review discusses genetic and nutritional causes of hair loss, highlighting that around 90% of treated men show noticeable hair regrowth with a dual inhibitor, while women's hair loss may improve by correcting iron and l-lysine deficiencies.

In this study, a marine protein-based agent improved hair growth in subjects with various types of hair loss over a 12-month period, with good tolerability and no reported side effects.

This case report identifies alopecia universalis in a worker as a result of occupational selenium intoxication.

This study reported that oral zinc therapy improved hair and skin abnormalities in patients with dry brittle hair, alopecia, and other symptoms, regardless of demonstrated zinc deficiency.

This study reported that a 19-year-old man's essential fatty acid deficiency was reversed with daily topical application of linoleic acid, improving clinical symptoms and normalizing certain fatty acid levels.