February 201923
A committee on female pattern hair loss recommended screening all women for androgen excess and starting 5% minoxidil. A meta-analysis comparing dutasteride with finasteride found dutasteride outperformed finasteride on hair count, with similar rates of sexual side effects. Topical minoxidil across non-scarring alopecias was found effective, with combinations outperforming monotherapy. Men with pattern hair loss had lower serum zinc than controls, prompting suggestions of zinc supplementation. JAK inhibitors for alopecia areata showed most patients responded, but recurrences followed stopping treatment. An antioxidant lotion in breast cancer patients did not prevent chemotherapy-induced alopecia but may promote recovery. Exome sequencing in women of African ancestry identified PADI3 variants associated with central centrifugal cicatricial alopecia.
- Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee Expert committee recommends assessing androgen excess in all women with female pattern hair loss and starting treatment with 5% minoxidil, adding antiandrogens if severe.
- The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review A systematic review found topical minoxidil effective for pattern hair loss with 17–70% hair growth increases, and combinations outperforming monotherapy.
- The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis Meta-analysis of 576 men: dutasteride outperformed finasteride on hair count and global assessments at 24 weeks, with similar rates of sexual side effects.
- The utility of DHL-HisZnNa, a novel antioxidant, against anticancer agent-induced alopecia in breast cancer patients: a multicenter phase II clinical trial In 100 breast cancer patients, 1% DHL-HisZnNa lotion did not prevent chemotherapy-induced alopecia but may promote recovery.
- JAK inhibitors for alopecia areata: a systematic review and meta‐analysis Meta-analysis of 289 alopecia areata cases found 72.4% responded to JAK inhibitors, but all recurrences happened after stopping treatment.
- Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice In mice, the iron chelator M30 prevented cyclophosphamide-induced hair loss and enhanced hair growth, identifying five protective genes.
- Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia Exome sequencing identified PADI3 gene variants associated with central centrifugal cicatricial alopecia in women of African ancestry.
- Serum biotin and zinc in male androgenetic alopecia Men with pattern hair loss had lower serum zinc and suboptimal biotin than matched controls, leading authors to suggest zinc supplementation.
- Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/��-Catenin Signaling Activation in 3-Dimensional-Spheroid Cultured Human Dermal Papilla Cells Silibinin increased hair-inductive gene expression in 3D-cultured human dermal papilla cells via Akt and Wnt/beta-catenin signaling.
- The influence of methotrexate on hair loss while using immunomodulatory doses. In a survey of 68 patients on immunomodulatory-dose methotrexate, 29.4% reported increased hair loss after starting treatment.
- Methods of treatment patients with androgenetic alopecia based on reference of Department of Dermatology in Cracow. A Cracow dermatology clinic treated pattern hair loss mostly with minoxidil 5%, with polytherapy common in women and hypothyroidism in 10.6% of patients.
- TSA restores hair follicle-inductive capacity of skin-derived precursors In cell culture, TSA treatment restored the hair-inducing capacity of skin-derived precursors by increasing BMP signaling.
- Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression Expression levels of the prostaglandin D2 receptor 2 regulate hair regression.
- Use of human intra-tissue stem/progenitor cells and induced pluripotent stem cells for hair follicle regeneration. A review summarizing strategies to bioengineer human hair follicles using hair follicle stem cells and induced pluripotent stem cells, with technical hurdles remaining.
- Alopecia and techniques in hair restoration: an overview for the cosmetic surgeon A review outlining follicular unit extraction and strip harvest transplantation techniques, noting robotics and PRP as adjuvants.
- The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles In mice, BMP6 inhibits while Wnt10b activates hair follicle stem cells, and their balance controls the telogen-to-anagen transition.
- The use of heat and chemical penetration enhancers to increase the follicular delivery of erythromycin to the skin Heat plus chemical penetration enhancers synergistically increased follicular delivery of erythromycin into human skin.
- Differential expression patterns of specific long noncoding RNAs and competing endogenous RNA network in alopecia areata Blood profiling found 154 differentially expressed lncRNAs and a competing endogenous RNA network linked to alopecia areata.
- Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate—A perplexing perspective A review examining the conflicting evidence on whether estrogens stimulate or inhibit scalp hair growth, concluding mechanisms remain unclear.
- Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling In mice, Activin B accelerated whisker growth by stimulating hair matrix cell proliferation through ERK signaling.
- Transepidermal UV radiation of scalp skin <i>ex vivo</i> induces hair follicle damage that is alleviated by the topical treatment with caffeine In ex vivo human scalp skin, UV radiation damaged hair follicles and promoted catagen, while topical caffeine 0.1% partly protected follicles from this damage.
- Prostaglandins in androgenetic alopecia in 12 men and four female Prostaglandins were studied in 12 men and 4 women with androgenetic alopecia.
- Differential distribution of the epigenetic marker 5‐hydroxymethylcytosine occurs in hair follicle stem cells during bulge activation In mouse and human follicles, the epigenetic marker 5-hmC appears in bulge stem cells during early anagen, suggesting a role in hair cycle activation.