October 201922
A meta-analysis found traditional Chinese medicine added to conventional treatment improved efficacy in androgenetic alopecia with similar adverse events. A meta-analysis for surgeons reported transplant graft survival of 85-93% and satisfaction of 90-97% in nonscarring alopecia. In a placebo-controlled trial, monofilament thread scalp injections improved hair mass and count in women with pattern hair loss. In a randomized crossover trial, topical minoxidil versus PRP in women showed minoxidil improved more hair measures, while PRP improved quality-of-life scores. Progenitor-cell-enriched scalp micrografts were reported to improve hair count, density and anagen phase. In uncontrolled patients, four PRP sessions increased hair density through seven months. In mice, boehmite applied to skin accelerated hair regrowth via β-catenin signalling.
- Meta-Analysis on the Efficacy and Safety of Traditional Chinese Medicine as Adjuvant Therapy for Refractory Androgenetic Alopecia A meta-analysis of 30 RCTs found adding traditional Chinese medicine to conventional treatment improved efficacy in androgenetic alopecia, with similar adverse events, though higher-quality long-term trials are needed.
- Contemporary Management of Alopecia: A Systematic Review and Meta-analysis for Surgeons Meta-analysis of 57 studies found hair transplant graft survival of 85-93% and satisfaction of 90-97% in nonscarring alopecia.
- Monofilament threads in treatment of female hair loss In a placebo-controlled trial, monofilament thread scalp injections significantly improved hair mass and count in women with female pattern hair loss.
- A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women In a randomized crossover trial of 20 women with AGA, topical minoxidil improved more hair measures than PRP, though PRP improved quality-of-life scores.
- Progenitor‐cell‐enriched micrografts as a novel option for the management of androgenetic alopecia Progenitor-cell-enriched scalp micrografts improved hair count, density and anagen phase over 12 months in androgenetic alopecia patients.
- Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β‐catenin signalling In mice and cultured dermal papilla cells, boehmite accelerated hair regrowth via β-catenin signalling.
- Alopecia and Hair Damage Induced by Oncological Therapy A review of oncology-treatment hair loss: risk varies by drug and dose, alopecia is mostly reversible but can be permanent, and scalp cooling plus minoxidil aid prevention and regrowth.
- The Clinical Efficacy and Safety of Autologous Activated Platelet-Rich Plasma Injection in Androgenetic Alopecia In 24 uncontrolled AGA patients, four PRP sessions significantly increased hair density at all time points through 7 months, with only mild injection pain.
- Oral bicalutamide for female pattern hair loss: A pilot study a pilot study of oral bicalutamide for female pattern hair loss.
- Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia HA-PLGA nanoparticles delivered minoxidil to hair follicle cells without cytotoxicity in lab and skin permeation tests.
- Eyebrow Hair Transplantation in Frontal Fibrosing Alopecia: Pitfalls of Short- and Long-Term Results In ten FFA patients, eyebrow transplants looked excellent at 6-12 months but most lost the grafts after 3-4 years.
- Scalp Micro-Pigmentation via Transcutaneous Implantation of Flexible Tissue Interlocking Biodegradable Microneedles Biodegradable microneedles implanted micro-pigment accurately and stably in pig cadaver skin, a possible future scalp micro-pigmentation platform.
- Experience with oral tofacitinib in two adolescents and seven adults with alopecia areata In nine alopecia areata or universalis patients, oral tofacitinib produced a 41% clinical response rate over 6 months with mild adverse effects.
- Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata A scoping review of JAK/STAT inhibitors found varied alopecia areata responses and mostly mild adverse events, with evidence still low quality.
- Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression with Alopecia Areata in Males: A Case–control Study In a case-control study of 337 men, the AIRE rs2075876 G variant was strongly associated with alopecia areata risk, unrelated to gene expression levels.
- Frontal fibrosing alopecia in Asians: a retrospective clinical study In 56 Thai FFA patients, topical corticosteroids combined with hydroxychloroquine or finasteride best stabilized disease progression.
- Pigmentation Effect of Rice Bran Extract in Hair Follicle-Like Tissue and Organ Culture Models Rice bran ash extract increased melanin-producing protein expression in hair follicle-like tissue and organ culture models.
- Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding A review of wound-induced hair follicle regeneration, where Wnt, TLR3, inflammatory and Shh signals drive new follicle formation in adult skin.
- Frontiers in alopecia areata pathobiology research A review highlighting NK cells, unconventional T cells and immune-privilege defects as emerging therapeutic targets in alopecia areata.
- In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin In vitro, 5 µM simvastatin induced hair follicle stem cells to differentiate into keratinocytes.
- Hair Growth Promoting Effect of <i>Hottuynia cordata</i> Extract in Cultured Human Hair Follicle Dermal Papilla Cells Houttuynia cordata extract stimulated dermal papilla cell proliferation and prolonged anagen in cultured human hair follicles.
- Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth Chitosan hydrogel nanoparticles delivering fermented herbal extract penetrated skin and enlarged hair bulbs in telogenic mice.