July 201927
Adipose follicle stem-cell micrografts raised hair density about 27-33% in a split-scalp trial. A tyramine-based shampoo was found to cut hair shedding during brushing by 31%. Graft transection rates in FUE rose sharply by the end of large sessions, suggesting surgeon fatigue damages grafts. Cannabidiol in human hair follicles was reported to act dose-dependently, anti-inflammatory at low doses but growth-inhibitory at high doses. In alopecia areata, erbium-glass laser sessions with minoxidil raised response from 16% to 60%, and a trichoscopy-based score predicted regrowth probability from 0% to 98%.
- Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia In a small split-scalp trial, adipose follicle stem-cell micrografts raised hair density about 27-33% versus baseline.
- Novel shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine‐associated receptor In a small crossover study, a tyramine-based shampoo contracting the arrector pili muscle cut hair shedding during brushing by 31%.
- The Phytocannabinoid (–)-Cannabidiol Operates as a Complex, Differential Modulator of Human Hair Growth: Anti-Inflammatory Submicromolar versus Hair Growth Inhibitory Micromolar Effects Cannabidiol modulates human hair growth in a dose-dependent way, anti-inflammatory at low doses but growth-inhibitory at high doses.
- An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth In mice, skin lymphatic vessels promote anagen hair growth, and VEGF-C injections boosted hair growth, pointing to new targets.
- An important role of podoplanin in hair follicle growth In mice, deleting podoplanin from keratinocytes promoted anagen hair follicle growth, suggesting new therapeutic strategies for hair loss.
- Impact of a topical lotion, CG428, on permanent chemotherapy-induced alopecia in breast cancer survivors: a pilot randomized double-blind controlled clinical trial (VOLUME RCT) A small trial of botanical lotion CG428 in breast cancer survivors with permanent chemo-induced alopecia showed only a nonsignificant density trend.
- The Use of a 1,540 nm Fractional Erbium‐Glass Laser in Treatment of Alopecia Areata In a trial of alopecia areata patches, adding six erbium-glass laser sessions to minoxidil raised hair growth response from 16% to 60%.
- Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen–anagen transformation In human scalp follicles, anagen induction raises Wnt ligands WNT3, WNT4, WNT10B and lowers inhibitor SFRP1, suggesting drug targets.
- Effect of surgeon's workload on rate of transection during follicular unit excision/extraction (FUE) In 25 FUE patients, graft transection rates rose sharply by the end of large sessions, suggesting surgeon fatigue damages grafts.
- Alopecia areata predictive score: A new trichoscopy‐based tool to predict treatment outcome in patients with patchy alopecia areata In 65 patchy alopecia areata patients, a trichoscopy score at 2 months predicted 6-month regrowth probability from 0% to 98%.
- Weekly azathioprine pulse versus betamethasone oral mini-pulse in the treatment of moderate-to-severe alopecia areata In a 50-patient randomized trial, weekly azathioprine pulse matched betamethasone mini-pulse for alopecia areata regrowth with significantly fewer side effects.
- Overexpression of alkaline phosphatase improves the hair-inductive capacity of cultured human dermal papilla spheres Overexpressing alkaline phosphatase improved the hair-inductive capacity of cultured human dermal papilla spheres.
- Using the combination of the Kerure clamp and serrated punch to decrease the transection rate in follicular unit extraction combining the Kerure clamp with a serrated punch is proposed to lower transection rates in follicular unit extraction.
- 2‐deoxy D‐glucose treatment does not elicit a hair growth response in alopecia areata In a mouse model of alopecia areata, 16 weeks of oral 2-deoxy-D-glucose failed to stop hair loss or regrow hair.
- Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules In mice, nanoparticle-encapsulated herbal mixture 4HGF lengthened hair and prolonged anagen via beta-catenin activation.
- Utility of laboratory testing in patients with female pattern hair loss A look at the usefulness of laboratory testing in women with female pattern hair loss.
- A Comparison of Apoptotic Activity for Follicular Unit Extraction Hair Grafts Stored in Different Holding Solutions A comparison of apoptotic activity in FUE hair grafts stored in different holding solutions.
- Trichoscopy of alopecia areata in children. A retrospective comparative analysis of 50 children and 50 adults In 50 children with alopecia areata, yellow dots were rarer and pigtail hairs and empty follicles more common than in 50 adults.
- Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease Alopecia areata patients show a deficiency of FOXP3+CD39+ regulatory T cells and restricted Treg receptor diversity, highlighting immune mechanisms.
- Design, synthesis, and biological activity of TLR7-based compounds for chemotherapy-induced alopecia Newly synthesized quinoline compounds acted as TLR7 antagonists, with one promoting hair follicle cell proliferation in early tests.
- Characterization of human dermal sheath cells reveals CD36-expressing perivascular cells associated with capillary blood vessel formation in hair follicles Human dermal sheath cells expressing CD36 associate with capillary networks in hair follicles, linking them to hair cycling angiogenesis.
- Distribution of polyamines may be altered in different scalp regions of patients with hair loss Polyamine levels, especially N-acetyl polyamines, differed between vertex and occipital scalp hair in pattern hair loss patients.
- Cholesterol homeostasis: Links to hair follicle biology and hair disorders A review links cholesterol homeostasis to hair follicle biology and several hair disorders, though mechanisms remain largely unknown.
- Chemically induced transformation of human dermal fibroblasts to hair‐inducing dermal papilla‐like cells Researchers chemically converted human dermal fibroblasts into hair-inducing dermal papilla-like cells as a step toward cell-based hair regeneration.
- Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration In mice, conditioned medium from Nanog-overexpressing amniotic stem cells sped hair regrowth and increased follicle density.
- FDA Reports of Alopecia as an Adverse Event to Isotretinoin An analysis of FDA reports of alopecia as an adverse event of the acne drug isotretinoin.
- Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature Gene expression from plucked hair follicles distinguished discoid lupus scalp lesions from psoriasis and healthy follicles without biopsy.