June 201935
Six monthly PRP sessions improved density and thickness, with early-stage patients responding best. A meta-analysis of PRP injections found increased hair count and terminal density versus controls, though study quality was low. A systematic review of PRP advocated three to four monthly sessions while urging standardized protocols. Finasteride 1mg over 24 months showed improvement came from residual terminal follicles while miniaturized hairs kept regressing, challenging the reversal idea. Three microneedling sessions reduced hair loss and improved density in mixed alopecia. Biofibre artificial hair implants gave immediate cosmetic results without scarring or hospitalization. In mice, noncoding dsRNA via TLR3 drove retinoic acid synthesis predicting new follicle formation after wounding.
- Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades In 93 patients, six monthly PRP sessions improved density and thickness, with early-stage (Grade II-III male, Grade I female) patients responding best.
- Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review A systematic review of 19 studies advocates PRP in 3-4 monthly sessions for alopecia, while urging standardized protocols.
- Viable terminal scalp hair follicles constitute a necessary and sufficient biological end‐organ that conditions clinical efficacy of finasteride in males with male pattern hair loss without implying reversal of miniaturized follicles A 24-month study of 13 men on finasteride 1mg found improvement came from residual terminal follicles while miniaturized hairs kept regressing, challenging the 'reversal' idea.
- Platelet-Rich Plasma for Treating Androgenic Alopecia: A Systematic Review A meta-analysis of 11 studies (262 patients) found PRP injections increased hair count and terminal hair density versus controls, though study quality was low.
- Preliminary results of the use of scalp microneedling in different types of alopecia In 50 patients, three microneedling sessions over six months reduced hair loss and improved density without serious side effects.
- Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3 In mice, noncoding dsRNA activates TLR3 to drive retinoic acid synthesis that predicts new hair follicle formation after wounding.
- Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin Fibroblast extracellular vesicles stimulated hair-follicle growth ex vivo via dermal papilla-secreted Norrin activating beta-catenin.
- Biofibre® Artificial Hair Implant : Retrospective Study on 1.518 Patients with alopecia and Present Role in Hair Surgery A retrospective series of 1,518 patients reports artificial Biofibre hair implants gave immediate cosmetic results without scarring or hospitalization.
- Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath In mice, blocking TRPV3 channels with forsythoside B reversed hair-growth inhibition, suggesting a new hair-loss therapy target.
- Stimulation of Hair Growth by Small Molecules that Activate Autophagy In mice, autophagy-activating molecules including rapamycin and metformin triggered anagen and hair growth, and oral alpha-KB prevented age-related hair loss.
- Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata apremilast and tofacitinib showed differing effects in a humanized mouse model of alopecia areata.
- Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects A study of 256 people found androgenetic alopecia independently associated with asymptomatic brain white matter hyperintensities, a marker of small vessel disease.
- Investigation on Microecology of Hair Root Fungi in Androgenetic Alopecia Patients A study found higher scalp Malassezia loads in androgenetic alopecia patients, correlating the yeast with the condition.
- Can plant‐derived phytochemicals provide symptom relief for hair loss? A critical review A review critically evaluates evidence for plant-derived phytochemicals in hair loss, excluding animal data, and recommends better study methods.
- Tratamiento con tofacitinib en adolescentes con alopecia areata Spanish-language case series: oral tofacitinib gave moderate regrowth in four adolescents with severe alopecia areata.
- Reliability of Histopathology for the Early Recognition of Fibrosis in Traction Alopecia: Correlation with Clinical Severity In 45 traction-alopecia patients, scalp-biopsy fibrosis grading agreed poorly between pathologists and did not match clinical severity.
- Treatment of chronic extensive alopecia areata by diphenylcyclopropenone alone versus in combination with anthralin In 24 chronic extensive AA patients, DPCP alone outperformed DPCP plus anthralin, with 62.5% vs 18.2% complete regrowth.
- Janus kinase inhibitors: An innovative treatment for alopecia areata A review finds oral JAK inhibitors effective and tolerable for moderate-to-severe AA, but calls for placebo-controlled trials.
- Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial In a 60-patient trial, topical calcipotriol and narrowband UVB each improved alopecia areata severity and vitamin D3 levels versus placebo.
- Evolution of Hair Treatment and Care: Prospects of Nanotube-Based Formulations In lab tests, drug- or dye-loaded clay nanotubes form washable coatings on hair for sustained delivery and coloring.
- Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues Cultured mouse dermal papilla cells induced hair follicle formation in engineered human skin grafted onto mice.
- Progressive expression of PPARGC1α is associated with hair miniaturization in androgenetic alopecia Transcriptome analysis implicates PPAR pathway and PPARGC1a alongside the androgen receptor in progressive hair follicle miniaturization.
- Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review A review finds limited evidence that fractional lasers and microneedling with topical agents may help alopecia areata.
- Wnt activator CHIR99021-stimulated human dermal papilla spheroids contribute to hair follicle formation and production of reconstituted follicle-enriched human skin Wnt activator CHIR99021 plus 3D spheroid culture generated human skin enriched with functional hair follicles in the lab.
- Association of cicatricial alopecia with chemical hair straightening A 286-patient clinic study found chemical hair straightening significantly more common in scarring alopecia, especially lichen planopilaris/frontal fibrosing alopecia, than in nonscarring controls.
- Frontal fibrosing alopecia: demographic and clinical characteristics of 490 cases In 490 frontal fibrosing alopecia patients, thyroid disease was common and cosmetic use did not correlate with disease activity.
- Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata A review covers regenerative treatments for vitiligo and AA, noting JAK inhibitors, bimatoprost, PRP and minoxidil benefits.
- The Effect of Platelet Rich Plasma on Hair Re‐growth in Patients with Alopecia Areata Totalis: a Clinical Pilot Study In 10 alopecia areata totalis patients, single intradermal PRP injections produced no significant hair regrowth over four months.
- Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study A gintonin-enriched ginseng fraction promoted hair growth in mice comparably to minoxidil, via dermal papilla cell proliferation.
- The diagnosis of androgenetic alopecia in children: Considerations of pathophysiological plausibility A review notes that pattern hair loss before puberty is rare and should prompt investigation for underlying hormonal abnormalities.
- Integrative analysis of rare copy number variants and gene expression data in alopecia areata implicates an aetiological role for autophagy Integrative analysis of 673 AA patients linked rare gene variants, including autophagy gene ATG4B, to disease signatures.
- Treatment of alopecia areata with nonablative fractional laser combined with topical minoxidil In 8 alopecia areata patients, fractional laser plus 5% minoxidil gave regrowth in all, with no relapse in most at one year.
- Association of type 2 diabetes with central-scalp hair loss in a large cohort study of African American women In 5,389 African American women, type 2 diabetes raised the risk of severe central scalp hair loss by 68%, doubling with 10+ years of disease.
- Efficacy and safety of anthralin in combination with diphenylcyclopropenone in the treatment of alopecia areata: a retrospective case series In 32 DPCP-nonresponsive AA patients, adding anthralin produced terminal regrowth in 41%, improving with longer treatment.
- The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics A review explores how extracellular vesicles may regulate hair follicle cycling and could inform future hair-loss therapies.