March 201927
Weekly mesotherapy for female pattern hair loss was found to match 5% minoxidil and increase follicle numbers. Three monthly PRP injections increased hair follicle number and thickness in men, while a PRP meta-analysis found injections increase hair density, recommending three monthly sessions with maintenance. A finasteride safety review outlined conflicting evidence on side effects, including persistent post-finasteride syndrome, proposing predisposing factors. A 762-man finasteride survey found users reported no more sexual dysfunction than non-users, though the study was survey-based. Proteomic analysis of scalp biopsies found 13 proteins changed after laser therapy, suggesting it reverses follicle miniaturization.
- Finasteride and androgenic alopecia; from therapeutic options to medical implications A review outlines conflicting evidence on finasteride side effects, including persistent post-finasteride syndrome, and proposes factors that may predispose some patients to adverse reactions.
- Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia A meta-analysis found PRP injections increase hair density and recommends three monthly sessions followed by maintenance every 3-6 months.
- The effect of platelet‐rich plasma injection in the treatment of androgenetic alopecia Three monthly PRP scalp injections significantly increased hair follicle number and thickness in men with androgenetic alopecia.
- Finasteride for androgenetic alopecia is not associated with sexual dysfunction: a survey‐based, single‐centre, controlled study In a 762-man survey, finasteride users reported no more sexual dysfunction than non-users, though self-report survey data cannot rule out individual susceptibility.
- Comparing the Efficacy of Mesotherapy to Topical Minoxidil in the Treatment of Female Pattern Hair Loss Using Ultrasound Biomicroscopy: A Randomized Controlled Trial. In a 30-patient trial, weekly mesotherapy matched 5% minoxidil for female pattern hair loss and increased follicle numbers, with higher patient satisfaction.
- Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres Exosomes from 3D-cultured dermal papilla cells elongated human hair shafts in culture and induced anagen in mice.
- A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth In mice, TREM2+ macrophages secrete oncostatin M to keep hair follicle stem cells dormant; blocking this reactivated hair growth.
- Development of finasteride polymer microspheres for systemic application in androgenic alopecia In mice, a single injection of finasteride-loaded microspheres produced hair growth equivalent to daily oral finasteride.
- In vivo and in vitro evaluation of hair growth potential of Cacumen Platycladi, and GC-MS analysis of the active constituents of volatile oil In mice, Platycladus orientalis volatile oil outperformed 2% minoxidil on hair growth speed and length and prolonged the anagen phase.
- Alopecia areata: a long‐term follow‐up study of 104 patients In 104 alopecia areata patients followed 7+ years, older onset meant better regrowth and fewer relapses; treatments did not alter long-term outcome.
- Quantitative proteomic analysis of dermal papilla from male androgenetic alopecia comparing before and after treatment with low‐level laser therapy Proteomic analysis of scalp biopsies found 13 proteins changed after 24 weeks of laser therapy, suggesting it reverses follicle miniaturization.
- Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia In 192 women with persistent post-chemotherapy alopecia, topical minoxidil or spironolactone produced moderate to significant improvement in about two-thirds.
- Minoxidil for patchy alopecia areata: systematic review and meta‐analysis A meta-analysis found 5% minoxidil clearly beats placebo for patchy alopecia areata, with moderate-quality evidence and no severe adverse events.
- Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle‐dependent manner In mice, injury recruited dermal stem cell progeny into the dermal papilla, biased by hair cycle stage, supporting wound-induced hair growth.
- Hair growth control by innate immunocytes: Perifollicular macrophages revisited A review of how perifollicular macrophages regulate the hair cycle and their potential as treatment targets.
- Effects of CO2 fractional laser on hair growth in C57BL/6 mice and potential underlying mechanisms In mice, fractional CO2 laser treatment promoted hair regrowth via wound-healing cytokines and Wnt pathway activation.
- Biofibre hair implant: what is new, what is true? A review describes Biofibre synthetic hair implants as safe, biocompatible and reversible, requiring yearly maintenance touch-ups.
- Cyproterone acetate-loaded nanostructured lipid carriers: effect of particle size on skin penetration and follicular targeting Lab study: 300 nm lipid nanoparticles loaded with cyproterone acetate best targeted hair follicles, a potential delivery system for androgenic skin disorders.
- The mechanism of activated platelet‐rich plasma supernatant promotion of hair growth by cultured dermal papilla cells In cultured dermal papilla cells, activated PRP supernatant activated growth-factor and Wnt signaling pathways linked to hair growth.
- Impact of Preservation Solutions on the Trichogenicity of Hair Micrografts Ascertained by Dermal Papilla Gene Expression Chilled ATPv-supplemented saline best preserved trichogenic gene expression in stored hair grafts for follicular unit excision.
- Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS In cultured human hair follicles, a transient burst of endogenous ROS activated stem cells and promoted entry into the growth phase.
- What’s New in Hair Loss A review of recent updates on retinoids for frontal fibrosing alopecia, PRP for pattern hair loss, and JAK inhibitors for alopecia areata.
- Adverse Hair Reactions to New Targeted Therapies for Cancer A review cataloguing hair changes caused by targeted cancer therapies, including altered growth, color and shape.
- Exposure to 50 Hz electromagnetic fields enhances hair follicle regrowth in C57BL/6 mice In mice, 50 Hz electromagnetic field exposure accelerated hair follicle regrowth via stem cell proliferation and growth factor expression.
- The role of photobiomodulation when associated with microneedling in female pattern hair loss A trial protocol describing a planned 66-patient study of red-laser photobiomodulation combined with microneedling for female pattern hair loss.
- Evaluating hair growth promoting effects of candidate substance: A review of research methods A review of laboratory methods used to evaluate candidate hair-growth substances, from cell assays to animal models.
- Hair transplantation in patients with hair loss or scar deformity in the side hairline after midfacelifting surgery In 37 patients, hair transplantation effectively corrected altered side hairlines and scars after midfacelift surgery, with high satisfaction.