September 201623
Men with persistent sexual symptoms after finasteride showed no androgen deficiency or enzyme inhibition but depressed mood and fMRI findings consistent with depression. 5-alpha reductase inhibitors in UK cohorts did not significantly raise erectile dysfunction risk, including finasteride 1 mg for alopecia. Men stopping finasteride 1 mg had a higher rate of sexual dysfunction diagnoses than matched omeprazole users. Two placebo-controlled trials reported PRP injections in women did not significantly improve hair count or mass, and PRP in men with androgenetic alopecia did not improve hair counts. Topical sphinganine in diffuse thinning reduced hair loss and improved hair and scalp quality. Platelet-rich fibrin matrix added to transplantation progressively increased follicle counts over six months. A review of nine LLLT trials found the evidence weak, citing small samples and inconsistent measures.
- Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss Men with persistent sexual symptoms after finasteride showed no androgen deficiency or persistent enzyme inhibition, but had depressed mood and fMRI findings consistent with depression.
- Risk of erectile dysfunction associated with use of 5-α reductase inhibitors for benign prostatic hyperplasia or alopecia: population based studies using the Clinical Practice Research Datalink Large UK cohort studies found 5-alpha reductase inhibitors did not significantly raise erectile dysfunction risk, including finasteride 1 mg for alopecia; risk rose with longer BPH duration instead.
- Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss Men who stopped finasteride 1 mg had a higher rate of sexual dysfunction diagnoses than matched omeprazole users (HR 1.62), seeking care up to a year later.
- Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia In a placebo-controlled pilot trial, PRP scalp injections did not significantly improve hair count or hair mass in women with female pattern hair loss.
- Efficacy of platelet-rich plasma in the treatment of androgenetic (male-patterned) alopecia: A pilot randomized controlled trial In a small randomized trial, PRP injections did not improve hair counts in men with grade 4-6 androgenetic alopecia.
- Effect of the multifunctional cosmetic ingredient sphinganine on hair loss in men and women with diffuse hair reduction In a placebo-controlled trial, topical sphinganine, a 5-alpha-reductase inhibitor, reduced hair loss and improved hair and scalp quality in men with diffuse thinning.
- Results of scalp cooling during anthracycline containing chemotherapy depend on scalp skin temperature duplicate
- Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata In 66 patients with severe alopecia areata, tofacitinib gave 50%+ regrowth in 32%, but hair was lost about 8.5 weeks after stopping.
- Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata In an open-label trial, oral ruxolitinib produced an average 92% hair regrowth in 9 of 12 patients with moderate-to-severe alopecia areata.
- A Critical Assessment of the Evidence for Low-Level Laser Therapy in the Treatment of Hair Loss A review of nine LLLT trials finds evidence weak—small samples, no visual evidence, inconsistent measures—and calls for standardized longer trials.
- Comparative Study of a Novel Tool for Follicular Unit Extraction for Individuals with Afro-textured Hair A curved nonrotary punch kept follicle transection under 5% in FUE for tightly curled Afro-textured hair, where rotary punches failed.
- Study on the Efficacy of Platelet-rich Fibrin Matrix in Hair Follicular Unit Transplantation in Androgenetic Alopecia Patients. In 10 men, adding platelet-rich fibrin matrix to follicular unit transplantation progressively increased hair follicle counts over six months.
- Primary scalp alopecia: new histopathological tools, new concepts and a practical guide to diagnosis A review offers a simplified diagnostic pathway for primary scalp alopecias, covering tissue processing and immunohistochemistry.
- Eccrine Duct Dilation as a Marker of Cicatricial Alopecia Eccrine duct dilation was found in 35% of cicatricial versus 4% of noncicatricial alopecia biopsies, a useful diagnostic clue.
- A study of the efficacy of platelet-rich plasma in the treatment of androgenetic alopecia in males a study of platelet-rich plasma efficacy for male androgenetic alopecia.
- Pregnancy and the hair growth cycle: anagen induction against hair growth disruption using Nourkrin<sup>®</sup> with Marilex<sup>®</sup>, a proteoglycan replacement therapy A review finds no postpartum hair-loss treatment adequately proven, and proposes proteoglycan replacement (Nourkrin with Marilex) as an anagen inducer.
- A New Subtype of Lichen Planopilaris Affecting Vellus Hairs and Clinically Mimicking Androgenetic Alopecia A new lichen planopilaris subtype affecting vellus hairs can mimic androgenetic alopecia, and misdiagnosis risks harm from transplant or wrong therapy.
- Estimated serum vitamin D status, vitamin D intake, and risk of incident alopecia areata among US women In 55,929 US women, estimated vitamin D status and intake showed no association with developing alopecia areata.
- Female pattern hair loss, biological ageing and the Leiden Longevity study examines female pattern hair loss and biological ageing in the Leiden Longevity study.
- Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern? review asks whether adverse effects of 5-alpha reductase inhibitors in androgenetic alopecia are cause for concern.
- A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia A review proposes PRP promotes hair growth via growth-factor activation of Wnt/beta-catenin, ERK and Akt pathways, extending anagen.
- Prevalence of fronto-vertex baldness and its association with family history of androgenetic alopecia in Korean men using basic and specific classification prevalence of fronto-vertex baldness and family history association in Korean men.
- Innovative modified hair follicle harvesting technique with reverse rake scalp elevator for lower occipital donor area in follicular unit extraction hair transplantation A reverse rake scalp elevator technique lowers transection rates when harvesting FUE grafts from the lower occipital donor area.