December 201615
In young men with lasting symptoms after finasteride, androgen-receptor gene repeat lengths tracked with specific symptom patterns, though causality remains unproven. Scalp laxity and elasticity predicted donor strip scar width in hair-transplant patients. Early-onset pattern hair loss was linked to higher oxidative stress markers than controls. Greater baldness severity independently predicted cancer risk at prostate biopsy. In mice, early-passage dermal papilla secretions regenerated hair. A normal hair pull test was found to be two hairs or fewer.
- Androgen Receptor (<i>AR</i>) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia In 66 men with post-finasteride symptoms, androgen-receptor gene repeat lengths tracked with specific symptom patterns; causality unproven and further study needed.
- Long-term efficacy and safety of the dual 5-alpha reductase blocker dutasteride on male androgenetic alopecia patients a long-term efficacy and safety study of dutasteride for male pattern hair loss.
- Association Between Scalp Laxity, Elasticity, and Glidability and Donor Strip Scar Width in Hair Transplantation and a New Elasticity Measuring Method In 88 hair-transplant patients, scalp laxity and elasticity predicted donor strip scar width; a new elasticity measure is proposed.
- Hair pull test: Evidence-based update and revision of guidelines A 181-person study found normal hair pull test should be 2 hairs or fewer, with no need to restrict washing or brushing.
- The role of oxidative stress in early-onset androgenetic alopecia Young men with early-onset pattern hair loss had higher oxidative stress markers than controls; antioxidants speculated as treatment.
- The association of male pattern baldness and risk of cancer and high-grade disease among men presenting for prostate biopsy In 394 men undergoing prostate biopsy, greater baldness severity independently predicted cancer and high-grade disease risk.
- iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration Early-passage dermal papilla cell secretions regenerate hair in mice; SDF1, MMP3, biglycan and LTBP1 are candidate factors.
- Frontal fibrosing alopecia: a pathology on the rise A 77-year-old woman's frontal fibrosing alopecia improved on finasteride 2.5 mg daily; a case report.
- Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature A review finds JAK inhibitors promising for alopecia areata and other skin diseases but too early for firm conclusions.
- Increased blood levels of NKG2D+CD4+ T cells in patients with alopecia areata NKG2D+CD4+ T cells are elevated in the blood of alopecia areata patients.
- Immune-related alopecia (areata and universalis) in cancer patients receiving immune checkpoint inhibitors Four cancer patients developed alopecia areata or universalis on checkpoint inhibitors; most regrew hair, with poliosis.
- Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny A new 3D culture system maintains hair follicle stem cells and reveals bidirectional interconversion with their progeny.
- Absence of vitamin D receptor (VDR)‐mediated PPARγ suppression causes alopecia in VDR‐null mice In VDR-null mice, unchecked PPARγ causes alopecia; reducing PPARγ restored hair regrowth.
- Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation In mice, Gata6 protects hair follicle progenitors from proliferation-linked DNA damage, sustaining hair production.
- Efficacy of metformin in human single hair fibre by ATR-FTIR spectroscopy coupled with statistical analysis