July 201623
Once-daily 5% minoxidil foam in women significantly increased hair density versus vehicle, and the same foam against twice-daily 2% solution regrew hair but narrowly missed noninferiority. Topical cedrol from Platycladus orientalis in mice promoted hair growth, outperforming 2% minoxidil at the highest dose. Implanted human scalp stem cells in mice generated functional new hair follicles and sebaceous glands.
- Doppler laser imaging predicts response to topical minoxidil in the treatment of female pattern hair loss. Doppler laser imaging predicts response to topical minoxidil in female pattern hair loss.
- A Phase III, Multicenter, Parallel-Design Clinical Trial to Compare the Efficacy and Safety of 5% Minoxidil Foam Versus Vehicle in Women With Female Pattern Hair Loss. A phase III trial found once-daily 5% minoxidil foam significantly increased hair density versus vehicle at 12 and 24 weeks, well tolerated.
- Efficacy and Safety of Once-Daily Minoxidil Foam 5% Versus Twice-Daily Minoxidil Solution 2% in Female Pattern Hair Loss: A Phase III, Randomized, Investigator-Blinded Study. A phase III trial found once-daily 5% minoxidil foam regrew hair in female pattern hair loss but narrowly missed noninferiority to twice-daily 2% solution.
- Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis In mice, topical cedrol from Platycladus orientalis promoted hair growth, outperforming 2% minoxidil at the highest dose.
- Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors In mice, implanted human scalp-derived stem cells and skin precursors generated functional new hair follicles and sebaceous glands.
- Multi-therapies in androgenetic alopecia: review and clinical experiences A review of androgenetic alopecia treatments emphasizing early, indefinite, personalized therapy combining available options.
- Illuminating current pitfalls in optimal photobiomodulation device development and assessment for treating hair loss A commentary argues FDA 510(k) clearance and 5 mW ocular-safety limits—not efficacy evidence—explain why laser hair-growth devices share wavelengths and power, possibly limiting effectiveness.
- Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice In mice, topical cedrol partially prevented cyclophosphamide-induced hair loss where minoxidil did not.
- Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth In mice, activating β-catenin in CD133+ dermal papilla cells accelerated hair growth.
- The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis Microscopy study found the arrector pili muscle's attachment to the follicle bulge is lost or miniaturized in androgenetic alopecia.
- Epinephrine Vasoconstriction Effect Time in the Scalp Differs According to Injection Site and Concentration In 25 volunteers, scalp epinephrine vasoconstriction lasted longer at higher concentrations and at the frontotemporal junction than the midfrontal hairline.
- CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth In mice, Wnt signals from CD133+ dermal papilla cells are needed for normal postnatal hair growth.
- Intramuscular triamcinolone acetonide: An undervalued option for refractory alopecia areata In 27 patients with refractory alopecia areata, monthly intramuscular triamcinolone gave a 63% response; menstrual and bone side effects occurred only in women.
- Health-related quality of life (HRQoL) among patients with alopecia areata (AA): A systematic review A systematic review of 11 studies found alopecia areata patients consistently report poor quality of life, comparable to psoriasis or eczema.
- Efectos adversos de los inhibidores de la 5-alfa-reductasa en la alopecia androgenética masculina ¿hay por qué preocuparse? a Spanish-language review asking whether the adverse effects of 5-alpha-reductase inhibitors in male androgenetic alopecia are cause for concern.
- Asymmetry of the Receding Hairline in Men With Early Androgenetic Alopecia In 41 men with early pattern loss, frontotemporal recession was usually larger on the right side, a pattern Norwood staging misses.
- CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata In a mouse model, blocking the chemokine receptor CXCR3 prevented T-cell infiltration and development of alopecia areata.
- Female sexual dysfunction in androgenetic alopecia: Case-control study A case-control study of 212 premenopausal women found androgenetic alopecia independently associated with female sexual dysfunction.
- Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7 In mice, topical human placenta extract promoted hair regrowth and increased FGF-7 expression.
- Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression In mice, imiquimod applied in mid-to-late telogen activated hair follicle stem cells and triggered premature anagen via inflammatory macrophages, independent of Wnt.
- Immunopotentiator from Pantoea agglomerans 1 (IP-PA1) Promotes Murine Hair Growth and Human Dermal Papilla Cell Gene Expression. In mice and human dermal papilla cell cultures, a bacterial immunopotentiator promoted hair growth and increased FGF-7 and VEGF expression.
- Severity of Alopecia Predicts Coronary Changes and Arterial Stiffness in Untreated Hypertensive Men In 101 untreated hypertensive men, severe pattern hair loss was associated with impaired coronary flow reserve, suggesting higher cardiovascular risk.
- An investigation of crosstalk between Wnt/β-catenin and transforming growth factor-β signaling in androgenetic alopecia In scalp follicles from 15 men, balding areas showed reduced Wnt and elevated TGF-β signaling, with evidence of crosstalk between the pathways.