April 201629
Low-level laser therapy was found in a review to improve hair count and density, though the authors urged cautious interpretation. PRP injections for androgenetic alopecia increased hair density and anagen hairs in a placebo-controlled half-head trial. Psychosocial impairment in young men was associated with doubled odds of sexual dysfunction, relevant when weighing finasteride. 5α-reductase inhibitors in women were found to produce very few reported sexual side effects, though side-effect data remain sparse. Topical methyl vanillate raised hair count and hair mass index in an uncontrolled pilot.
- Low-level laser therapy as a treatment for androgenetic alopecia A review of 11 studies (680 patients) found most showed improved hair count and density with low-level laser therapy, urging cautious interpretation.
- Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia In a 25-patient placebo-controlled half-head trial, PRP injections increased hair density and anagen hairs in androgenetic alopecia.
- Side Effects Related to 5 α-Reductase Inhibitor Treatment of Hair Loss in Women: A Review. A review of 20 studies found very few sexual side effects reported when finasteride or dutasteride treated women's hair loss, while noting side-effect data are sparse.
- Psychosocial Impairment as a Possible Cause of Sexual Dysfunction among Young Men with Mild Androgenetic Alopecia: A Cross-sectional Crowdsourcing Web-based Study. A web survey of 190 young men with AGA found moderate-to-severe psychosocial impairment doubled odds of sexual dysfunction, relevant when weighing finasteride.
- Topical application of the Wnt/<i>β</i>-catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia In a 20-woman uncontrolled pilot, topical methyl vanillate raised hair count 6% and hair mass index 12% over six months.
- Neural Stem Cells Restore Hair Growth through Activation of the Hair Follicle Niche In mice, neural stem cell extract promoted hair growth by activating follicle niches via TGF-β and BMP signaling.
- Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion A review of 90 reports found major inconsistencies in light parameters for hair regrowth studies and calls for rigorous randomized trials.
- Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice In mice, topical lavender oil increased hair follicle number, depth and dermal thickness comparably to 3% minoxidil.
- Association of metabolic syndrome with female pattern hair loss in women: A case-control study A case-control study linked female pattern hair loss to metabolic syndrome, especially waist circumference and hypertension.
- Efficacy and Safety of Minoxidil 2% Solution in Combination With a Botanical Hair Solution in Women With Female Pattern Hair Loss/Androgenic Alopecia. In a 54-woman uncontrolled study, minoxidil 2% plus a botanical solution improved hair growth ratings by week 6.
- Efficacy and Safety of Minoxidil 5% Foam in Combination With a Botanical Hair Solution in Men With Androgenic Alopecia. In a 56-man uncontrolled study, minoxidil 5% foam plus a botanical solution improved coverage ratings by week 4.
- Hot water extract of oriental melon leaf promotes hair growth and prolongs anagen hair cycle: In vivo and in vitro evaluation Oriental melon leaf extract sped anagen entry in mice and prolonged anagen in cultured human hair follicles.
- Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients In 11 treatment-resistant alopecia universalis patients, 308-nm excimer light gave good responses in four.
- STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction In mice, STAT5 activation in the dermal papilla acts as a switch triggering natural anagen entry.
- The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model In pigs, negative-pressure skin treatment thickened epidermis, doubled vessel density and unexpectedly increased hair follicle numbers.
- Role of thymosin beta 4 in hair growth In mice, thymosin beta 4 appears to promote hair growth via Wnt/β-catenin signalling, raising VEGF and MMP-2.
- Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers One alopecia areata patient on oral tofacitinib had near-complete regrowth by four months, with relapse after stopping and biomarker shifts.
- Multiple courses of pulse corticosteroid therapy for alopecia areata Alopecia areata patients with under 50% hair loss responded fully to pulsed methylprednisolone; more extensive cases needed more courses.
- Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata In 20 DCP-nonresponder alopecia areata patients, adding topical imiquimod to DCP gave significantly better regrowth than DCP alone.
- Signalling couples hair follicle stem cell quiescence with reduced histone H3 K4/K9/K27me3 for proper tissue homeostasis In mice, quiescent hair follicle stem cells actively reduce histone methylation, a state required for proper hair cycling.
- Focal Photodamage on the Occipital Scalp A letter notes hair loss reduces scalp photoprotection and advises hats, SPF 30+ sunscreen, or umbrellas.
- Pulse corticosteroid therapy with oral dexamethasone for the treatment of adult alopecia totalis and universalis a study of pulsed oral dexamethasone for treating adult alopecia totalis and universalis.
- Hair transplantation in mice: Challenges and solutions A new mouse follicular transplant method gave 90% hair-shaft-producing grafts at six weeks, aiding skin research.
- Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse Human hair follicles express VIP receptors, downregulated in alopecia areata; VIP protected follicles from immune privilege collapse in vitro.
- Androgenetic alopecia. Modelling progression and regrowth Describes hair follicle miniaturization and cycle changes underlying pattern hair loss progression.
- Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Lab comparison of balding versus non-balding dermal papilla cells implicates AR, TWIST1 and SSPN as candidate AGA genes.
- Finasteride adverse effects in subjects with androgenic alopecia: A possible therapeutic approach according to the lateralization process of the brain A hypothesis paper speculates finasteride side-effect risk may relate to hand preference and sexual orientation, without new evidence.
- Are 2D:4D finger-length ratios an indicator of androgenetic alopecia in males? Men with androgenetic alopecia had lower right-hand 2D:4D finger ratios than controls, unrelated to severity.
- [CO-TRANSPLANTATION OF MOUSE EPIDERMIS AND DERMIS CELLS IN INDUCING HAIR FOLLICLE REGENERATION]. In mice, co-transplanted epidermal and dermal cells induced new hair follicle formation; dermal cells alone did not.