June 201620
Topical minoxidil on damp scalp was found to penetrate skin better than on dry scalp in vitro, suggesting improved efficiency. Men with early-onset pattern hair loss showed a hormonal profile resembling PCOS in women, indicating possible future metabolic and cardiovascular risk. Beta-catenin activation in CD133-positive dermal papilla cells was found to maintain hair-inducing ability in lab-grown skin. Self-assembling peptide hydrogel scaffolds supported stem cells to form new hair follicles in mice.
- Minoxidil topical treatment may be more efficient if applied on damp scalp in comparison with dry scalp In vitro skin experiments suggest applying topical minoxidil to a damp rather than dry scalp increases drug penetration and could improve effectiveness.
- Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity Activating beta-catenin in CD133+ dermal papilla cells maintained their hair-inducing ability and accelerated hair growth in reconstituted skin.
- A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women Men with early-onset pattern hair loss showed a PCOS-like hormonal profile, suggesting possible future risk of metabolic syndrome and cardiovascular disease.
- Self-assembling peptide hydrogel scaffolds support stem cell-based hair follicle regeneration A self-assembling RADA-PRG peptide hydrogel supported skin-derived precursor cells and produced de novo hair follicle formation in mice.
- Guidelines on Hair Restoration for East Asian Patients Expert guidelines cover hairline design, donor harvesting, and graft placement for hair transplantation in East Asian patients.
- Cornu cervi pantotrichum Pharmacopuncture Solution Facilitate Hair Growth in C57BL/6 Mice Topical deer antler (Cornu cervi pantotrichum) pharmacopuncture solution promoted hair growth in mice by stimulating follicle cell proliferation and FGF-7.
- Successful Treatment of Refractory Alopecia Areata Universalis and Psoriatic Arthritis, But Not of Plaque Psoriasis with Tofacitinib in a Young Woman Tofacitinib regrew hair in a young woman with refractory alopecia areata universalis and psoriatic arthritis, though her plaque psoriasis persisted.
- Commentary on: Body Hair Transplant by Follicular Unit Extraction: My Experience With 122 Patients Commentary noting body hair transplantation is complication-free but labor-intensive, with beard hair the best non-scalp donor source.
- Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? Psoriatic skin shows 91% sebaceous gland atrophy and downregulated lipid genes, possibly explaining hair loss in psoriatic lesions.
- Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with <i>MCHR2</i> A genomewide study of 585 alopecia areata patients links rare MCHR2 duplications to the disease, suggesting a pigmentation-related mechanism.
- Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate in Vivo Epidermal Structures In rats, sebaceous glands can capture adjacent hair follicle stem cells from small biopsies, enabling regrowth of epidermis, follicles and glands.
- Efficacy of tofacitinib in treatment of alopecia universalis in two patients Two patients with long-standing alopecia universalis regrew scalp, eyebrow, and body hair on tofacitinib 5 mg twice daily without significant side effects.
- Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: a descriptive-analytic study of 1200 Iranian men In 1,200 Iranian men, the 2D:4D finger ratio, a marker of prenatal androgen exposure, did not predict androgenetic alopecia development or severity.
- sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation In mice, epidermal overexpression of sPLA2-IIA depletes hair follicle stem cells and drives their differentiation via JNK/c-Jun activation.
- Regeneration of hair and other skin appendages: A microenvironment‐centric view A review of how the follicular stem cell niche, mechanical forces, and signaling pathways govern hair regeneration and possible therapeutic targets.
- Changing faces: can a new identity stop balding? Commentary discussing whether reprogramming dermal papilla identity could reverse follicle miniaturisation, highlighting a study linking SFRP2 to papilla inductivity.
- [Association of eight single nucleotide polymorphisms of chromosomes 20 and X with androgenetic alopecia among ethnic Han Chinese from Yunnan]. Three chromosome 20 SNPs were associated with androgenetic alopecia in Han Chinese men from Yunnan; the four X-chromosome SNPs were monomorphic.
- High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease In 50 chronic graft-vs-host disease patients, 20% had vitiligo or alopecia areata, linked to higher skin GVHD scores.
- Use of silicon for skin and hair care: an approach of chemical forms available and efficacy A review finds orthosilicic acid is the most bioavailable silicon supplement form, but clinical studies on safety and efficacy for skin and hair are still lacking.
- Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles In lab tests on human skin, magnesium ions penetrate the stratum corneum, with hair follicles significantly facilitating the permeation.