March 201619
A hypothesis paper proposed hand preference and sexual orientation may predict finasteride sexual side effects, which can persist after stopping, though preliminary data remain unvalidated. A trial in 22 Japanese men found topical Gly-Pro-Ile-Gly-Ser lotion increased the proportion of thick hairs versus placebo. Authors identified donor-site selection and graft angle among four keys to transplant results. In vitro, plucked hair follicles grew faster than conventional one-hair micrografts. A review of animal models explained how alopecia areata models established JAK inhibitors as therapeutic strategies.
- Are hand preference and sexual orientation possible predicting factors for finasteride adverse effects in male androgenic alopecia? A hypothesis paper proposes hand preference and sexual orientation may predict finasteride sexual side effects, which can persist after stopping; preliminary data only, not yet validated.
- The topical penta-peptide Gly-Pro-Ile-Gly-Ser increases the proportion of thick hair in Japanese men with androgenetic alopecia In 22 Japanese men with AGA, a penta-peptide lotion increased the proportion of thick hairs and improved baldness scores versus placebo over 4 months.
- Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies A review of alopecia areata animal models explains how they established JAK inhibitors, CD8/NKG2D cells and apremilast as therapeutic strategies.
- Evaluation Indicators of Aesthetic Effects on Hair Transplantation Authors identify donor-site selection, graft direction and angle, density, and follicle survival as the four keys to good transplant results.
- Experimental Evidence in Hair Restoration Procedures: Plucked Hair Survival and Growth Rate. In an in vitro model, plucked human hair follicles grew faster than conventional one-hair micrografts, supporting their less invasive use in hair transplantation.
- Relationship between androgenetic alopecia and cardiovascular risk factors according to BASP classification in Koreans In 1884 Koreans, pattern hair loss was associated with higher rates of hypertension, diabetes, smoking and metabolic syndrome, especially with greater severity.
- Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays In cell assays, a beta-sitosterol, thioctic acid and carnitine compound down-regulated androgen and inflammatory markers more than finasteride, a proof of concept only.
- The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle In knockout mice, maternal vitamin D-deficient low-calcium diet caused transient non-scarring alopecia that resolved spontaneously.
- Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata In alopecia areata patients' blood cells, intracellular Toll-like receptors 3, 7, 8 and 9 were upregulated alongside Th1/Th17 cytokine imbalances.
- Histopathologic diagnosis of multifactorial alopecia Review of 1360 scalp biopsies found 12.5% had multiple concurrent alopecia diagnoses, and presents an approach to diagnosing multifactorial alopecia.
- Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women In 323 middle-aged women, low HDL cholesterol and low IGF-1 were each associated with higher risk of hair loss; causality unproven.
- Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity In 333 scalp biopsies, Demodex was usually nonpathogenic, but 4 cases of Demodex folliculitis with hair loss responded completely to metronidazole.
- Staphylococcus aureus and chronic folliculocentric pustuloses of the scalp - cause or association? A review of 80 chronic scalp folliculitis cases examined whether Staphylococcus aureus is a cause or incidental finding.
- Dermal lymphatic dilation in a mouse model of alopecia areata In a mouse alopecia areata model, dermal lymphatic vessels were dilated without increased numbers, suggesting potential therapeutic targets.
- Janus Kinase Inhibitors against Other Biological Treatments in Alopecia Areata A review argues JAK inhibitors (ruxolitinib, tofacitinib, baricitinib) show promise reversing alopecia areata, unlike failed TNF and IL-12/23 biologics.
- Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment In mice, old hair follicles transplanted into young hosts resumed hair shaft growth with active stem cells, suggesting follicle aging may be reversible.
- The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development In mice, the Notch intracellular domain acts through a noncanonical, RBPj-independent mechanism during early hair follicle development.
- Hair regeneration using adipose-derived stem cells. A review describes adipose-derived stem cells and preconditioning methods (vitamin C, PDGF, hypoxia, UVB) to enhance hair regeneration.
- A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features A genome-wide scan in 6,000+ Latin Americans identified 18 loci influencing hair shape, greying, balding and facial hair features.