October 201618
FDA adverse-event reports on alopecia drugs linked finasteride more than minoxidil to sexual dysfunction in men and fetal harm in women, with some effects reportedly not yet on the label. Finasteride 1 mg patient information should address sexual dysfunction and suicidal ideation risks for men. Lipids in androgenetic alopecia were found altered in a meta-analysis, with higher cholesterol, triglycerides and LDL and lower HDL. Platelet-rich plasma for alopecia areata was reported to regrow hair faster and more effectively than minoxidil 5%. Superficial cryotherapy for alopecia areata gave recovery in 61% of cases, best with frequent early sessions.
- Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases An analysis of FDA adverse-event reports found finasteride more linked than minoxidil to sexual dysfunction in men and fetal harm in women; the authors note some effects are not yet on the label.
- Finasteride 1 mg in alopecia: sexual dysfunction, suicidal ideation. Providing balanced information to male patients is key. men taking finasteride 1 mg should get balanced information about sexual dysfunction and suicidal ideation risks.
- 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling In mice, topical 3-deoxysappanchalcone promoted anagen hair growth by stimulating dermal papilla proliferation via Wnt/beta-catenin and STAT signalling.
- Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation In a 90-patient alopecia areata trial, platelet-rich plasma regrew hair faster and more effectively than topical minoxidil 5%.
- Lipid profile in patients with androgenetic alopecia: a meta-analysis A meta-analysis of 19 studies found men with androgenetic alopecia have higher cholesterol, triglycerides and LDL, lower HDL.
- Efficacy and safety of superficial cryotherapy for alopecia areata: A retrospective, comprehensive review of 353 cases over 22 years In a 353-patient retrospective review, superficial cryotherapy gave recovery in 61% of alopecia areata patients, best with frequent early sessions.
- Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia In hamsters, arginine-loaded lipid nanoparticles accumulated in follicles and grew more new hair than plain arginine solution.
- Treating Alopecia Areata: Current Practices Versus New Directions A review outlines current alopecia areata treatments and emerging options including biologics, lasers and platelet-rich plasma.
- Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia In cultured dermal papilla cells, androgens raise Wnt blocker DKK1 and WNT10b can rescue blocked hair stem cell differentiation.
- Human platelet lysate versus minoxidil stimulates hair growth by activating anagen promoting signaling pathways In mouse follicle cell cultures, minoxidil and human platelet lysate both activated anagen-promoting pathways including Erk, Shh and beta-catenin.
- Alopecia areata: What’s new in epidemiology, pathogenesis, diagnosis, and therapeutic options? A review of 996 publications surveys current understanding of alopecia areata epidemiology, pathogenesis and treatments.
- Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog In mice, hair follicle transit-amplifying cells drive neighbouring fat-cell production by secreting Sonic Hedgehog.
- Activin A-induced signalling controls hair follicle neogenesis In hair reconstitution assays, activin A signalling proved critical for new hair follicle formation from dermal papilla spheres.
- Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition In cultured human scalp follicles, activating Nrf2 with sulforaphane protected against oxidative-stress-induced hair growth inhibition.
- Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 In cultured hair follicle stem cells, EGF drove proliferation via EGFR/ERK and AKT signaling and cell-cycle protein changes.
- Remarkable Improvement of Nail Changes in Alopecia Areata Universalis with 10 Months of Treatment with Tofacitinib: A Case Report A patient with alopecia universalis had hair regrowth and resolution of nail dystrophy after 10 months on tofacitinib.
- Gradient-dependent release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin In porcine ear skin, dye-labeled nanocarriers released their drug cargo inside hair follicles, with the drug penetrating slightly deeper than the carriers.
- Treating Trichotillomania (Hair‐Pulling Disorder) in a Child