February 201623
Long-term dutasteride in men improved hair growth over a year, with drug-related adverse events in 17% (mostly mild erectile dysfunction and decreased libido) and no withdrawals, though the open-label uncontrolled design limits interpretation. t-Flavanone lotion in men was reported to improve pattern hair loss and increase hair-anchoring strength. Androgenetic alopecia in men was associated with higher rates of metabolic syndrome and benign prostatic hyperplasia. A genomics review of male-pattern alopecia described twelve implicated regions and possible treatment targets. In mice, sulforaphane promoting hair regeneration accelerated DHT degradation. In mice, follicle stem-cell loss via COL17A1 degradation was reported to drive age-related hair loss.
- Long-term safety and efficacy of dutasteride in the treatment of male patients with androgenetic alopecia In a 52-week open-label study of 120 men, dutasteride 0.5 mg improved hair growth with 17% drug-related adverse events (mostly mild; erectile dysfunction, decreased libido) and no withdrawals; open-label, uncontrolled design.
- Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone In ob/ob mice, sulforaphane promoted hair regeneration by inducing liver enzymes that degrade DHT, lowering plasma DHT levels.
- Benign prostatic hyperplasia, metabolic syndrome and androgenic alopecia: Is there a possible relationship? In a cross-sectional study of 400 men, androgenetic alopecia was associated with higher rates of metabolic syndrome (51% vs 28%) and BPH (36% vs 6.8%), suggesting monitoring.
- t-Flavanone Improves the Male Pattern of Hair Loss by Enhancing Hair-Anchoring Strength: A Randomized, Double-Blind, Placebo-Controlled Study In a 30-week randomized double-blind trial, t-flavanone lotion significantly improved androgenetic alopecia and increased hair-anchoring strength by upregulating desmoglein.
- Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions toward Clinical Reality Human scalp follicles grafted onto immunodeficient mice reproduce cyclophosphamide-induced hair loss, providing a realistic model of chemotherapy hair loss.
- Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis In mice and human samples, age-related hair loss is driven by COL17A1 degradation causing hair follicle stem cells to be shed through the epidermis, miniaturizing follicles.
- Hunting the genes in male‐pattern alopecia: how important are they, how close are we and what will they tell us? A review describes 12 genomic regions implicated in androgenetic alopecia (including AR, HDAC4/9, WNT10A) and how genetics may reveal new treatment targets.
- Alopecia areata and health-related quality of life: a systematic review and meta-analysis A meta-analysis of 21 studies found alopecia areata significantly impairs quality of life, especially mental health; wigs helped, anxiety and depression worsened it.
- Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice In mice, dual BACE1/BACE2 inhibitor NB-360 caused dose-dependent irreversible hair depigmentation by blocking PMEL17 processing, without retinal pigment changes.
- Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review includingGRADEassessments Cochrane review: antiandrogens (flutamide, spironolactone) and combined oral contraceptives reduce hirsutism scores; metformin ineffective; evidence quality mostly low.
- Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroid of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration A hanging-drop 3D culture restored hair-inductive capacity to high-passaged human dermal papilla cells, which induced follicle neogenesis when coimplanted in nude mice.
- Ultrastructural localization of hair keratins, high sulfur keratin-associated proteins and sulfhydryl oxidase in the human hair Electron microscopy localized keratins, sulfur-rich keratin-associated proteins, and sulfhydryl oxidase in the cornification zone of the human hair shaft.
- Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and<i>UBTF</i>Genes In balding men, nucleolin, nucleophosmin and UBTF gene expression differed between hair loss and normal scalp sites, correlating with hair loss.
- Dermal sheath cells contribute to postnatal hair follicle growth and cycling dermal sheath cells contribute to postnatal hair follicle growth and cycling.
- Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma Lab work shows the OVOL1-OVOL2 axis patterns hair bulb differentiation and is altered in pilomatricoma; ketoconazole upregulated OVOL1 in cultured keratinocytes.
- Advances in Understanding Hair Growth A short review proposes hair follicle homeostasis works via opposing 'Yin Yang' influences and highlights glycans as potential growth-control elements.
- Aging, alopecia, and stem cells aging, alopecia, and stem cells.
- Foxc1 reinforces quiescence in self-renewing hair follicle stem cells In mice, Foxc1 reinforces hair follicle stem cell quiescence via Nfatc1 and BMP signaling; deleting it causes premature stem cell activation.
- Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation Histology of two transplant patients showed grafted follicles enlarged with thicker dermal sheaths and denser vascular networks, increasing hair shaft diameter.
- Distinguishing diffuse alopecia areata (AA) from pattern hair loss (PHL) using CD3+ T cells CD3+ T-cells within empty follicular fibrous tracts on biopsy distinguished diffuse alopecia areata from pattern hair loss with 96% sensitivity and 100% specificity.
- Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease RNA sequencing of mouse hair follicles, keratinocytes, and dermal papilla cells mapped cell-cycle gene expression; grafted follicles supported sustained hair growth.
- Alopecia in general medicine A review for general physicians discusses common hair loss causes and conditions associated with systemic disease, with no specific new findings.
- Biotechs target stagnant baldness market biotech companies are targeting the stagnant baldness market.