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Glossary Tumor Suppressor Gene

regulates cell growth by preventing uncontrolled cell division

A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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Research

5 / 1000+ results

research Epigenetic regulation in adult stem cells and cancers

20 citations , January 2013 in “Cell & Bioscience”

This review discusses recent findings on the epigenetic regulation of adult stem cells and cancer stem cells, highlighting shared and distinct features, and reports no new clinical results.

research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

19 citations , December 2015 in “Journal of Investigative Dermatology”

This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.

research Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis

10 citations , January 2004 in “Journal of Investigative Dermatology”

Krt6a-Cre transgenic mice help study gene effects on hair follicle development and tumor suppression.

research The Tumor Suppressor Actions of the Vitamin D Receptor in Skin

9 citations , October 2014

This chapter hypothesizes that vitamin D signaling in the skin may suppress UV radiation-induced epidermal tumor formation, reviewing potential mechanisms without reporting new clinical results.

research Removing all obstacles: A critical role for p53 in promoting tissue renewal

30 citations , April 2010 in “Cell Cycle”

This review discusses how the p53 tumor suppressor gene helps maintain adult tissue homeostasis by promoting the removal of DNA-damaged cells, with implications for treating age-related diseases and p53-deficient cancers; it reports no new results.

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Community Join

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community Testosterone and hair loss seeming irrelevance

82 upvotes 3 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

233 upvotes 10 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

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