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    Glossary Topical JAK Inhibitors

    medications applied to skin to block Janus kinase enzymes

    Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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    Research 10 of 1000+

    1. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019 · 277 citations
    2. Topical Janus kinase inhibitors for the treatment of pediatric alopecia areata Journal of the American Academy of Dermatology · 2017 · 83 citations
    3. Topical Janus kinase inhibitors: A review of applications in dermatology Journal of the American Academy of Dermatology · 2018 · 63 citations
    4. Treatment of alopecia universalis with topical Janus kinase inhibitors – a double blind, placebo, and active controlled pilot study International Journal of Dermatology · 2018 · 49 citations
    5. Topical JAK Inhibitors for the Treatment of Alopecia Areata and Vitiligo Current dermatology reports · 2017
    6. 43647 Treatment of Refractory Folliculitis Decalvans with the Topical JAK Inhibitor Tofacitinib Journal of the American Academy of Dermatology · 2023
    7. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    8. Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus Biologics: Targets & Therapy · 2011 · 9 citations
    9. Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors? International Journal of Dermatology · 2023 · 1 citations
    10. Review of the Literature: Topical JAK Inhibitors Showing Promise for Hair Loss! Hair transplant forum international · 2016
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    Community 10 of 1000+

    1. Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy Reddit · 6 Jan 2025
    2. Recommendation for Topical Androgen Inhibitor While on 0.5mg/Day Dutasteride Community · 20 Oct 2025
    3. Topical finasteride (P-3074) inhibits scalp DHT up to 70% Reddit · 22 Feb 2026
    4. No regrowth after oral min, topical fin, min, and tret: Aggressive diffuse/hairline recession in 2 years Reddit · 29 Aug 2024
    5. Stopped topical Minox and Fin for 2 years, started again and gained my old status back Reddit · 18 May 2024
    6. Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp Reddit · 19 May 2023
    7. My Estradiol was 52 pg/mL (high) should I avoid topical Fin? Reddit · 27 Jul 2021
    8. A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle Reddit · 13 May 2025
    9. Choose your topical antiandrogen and tell me why Reddit · 6 Aug 2024
    10. Topical Dutasteride 0.025% 2ml once a week Reddit · 18 Jul 2024
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    Learn 6 of 26

    1. PP405 mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials
    2. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    3. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    4. Valproic acid Anti-seizure and mood-stabilising drug
    5. Procyanidin Plant polyphenol found in apples and grape seeds
    6. Neem Oil Oil from the neem tree, used in traditional remedies
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