October 2014 in “Dialnet (Universidad de la Rioja)” This research concluded that Snail2's absence in myeloid progenitors promotes tumor progression in mice, and specific zinc fingers are crucial for Snail1 and Snail2's roles in establishing epithelial-to-mesenchymal transition.
May 2025 in “Science Advances” In this study, researchers reported that hair follicle stem cells maintain quiescence through a PIEZO1-dependent mechanism that senses mechanical forces and translates them into localized calcium influx, involving a transcriptional network that regulates cell adhesion and cytoskeleton-related genes.
16 citations
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March 2021 in “EvoDevo” This study found that zebrafish and sticklebacks, despite differences in their tooth regeneration structures, share a similar genetic program during tooth regeneration, suggesting a conserved "successional dental epithelium" in vertebrates.
4 citations
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January 1992 in “The Tohoku Journal of Experimental Medicine” In this study, chronic zinc chloride administration in mice led to the replacement of long coarse hairs with short fine hairs, while overall skin histology remained normal.
November 1979 in “PubMed”
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that Myelin Protein Zero-like 3 plays a crucial role in hair follicle cycling by regulating anagen and catagen phases, mediated through mitochondrial signaling mechanisms in both human and murine hair follicles.
73 citations
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June 2010 in “PLoS Genetics” This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.
21 citations
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June 2016 in “PloS one” This study found that MYC and FGF pathways are crucial for hair cell regeneration in chick and zebrafish models, suggesting potential targets for promoting hair cell regeneration in mammals.
This study using zebrafish observed that inherited coping styles had a stronger impact on responses to social defeat stress than social rank, with subordinate fish showing more vulnerability to health impairments, including gut inflammation and skin injuries.
19 citations
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January 1974 in “Laboratory animals” In this study, inducing zinc deficiency in recently weaned female Tan rabbits led to reduced food consumption, weight loss, and reproductive issues, including inactive uterine and ovarian changes.
September 2023 in “Plant journal” This study showed that the zinc finger protein GIS3 is important for root hair growth in Arabidopsis by regulating RHD2 and RHD4 genes, with application of ethylene and cytokinin helping restore root hair presence in mutated variants.
December 2021 in “Journal of Investigative Dermatology” This study reports that inhibition of Wnt/β-catenin signaling disrupts hemidesmosome organization in keratinocytes by altering the localization of components like plectin and collagen XVII.
September 2024 in “Genes” This study found that overexpressing CRABP1 in dermal papilla cells promotes their proliferation and influences key genes in the Wnt/β-catenin signaling pathway, which may offer insights into mechanisms controlling hair follicle development.
1 citations
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July 2024 in “New Phytologist” In this study, researchers identified that three homologous genes—ZmSPL10, ZmSPL14, and ZmSPL26—are crucial for the development of stigmatic papilla in maize, with triple knockout mutants lacking these genes showing almost no stigmatic papilla and significantly reduced kernel setting.
November 2022 in “Journal of Investigative Dermatology” This study provides evidence that ILC1-like cells can induce alopecia areata in previously healthy human hair follicles, challenging the view that it is solely an autoantigen-dependent autoimmune disease.
62 citations
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March 2017 in “Journal of Investigative Dermatology” Mutations in the ACTB gene cause Becker’s nevi and may lead to muscle issues in Becker’s nevus syndrome.
33 citations
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July 2007 in “Journal of cell science” This study found that knocking out the transactivation domain of Miz1 in mouse keratinocytes disrupted hair follicle orientation, caused irregular pigmentation, and increased keratinocyte proliferation, indicating Miz1's role in hair follicle development and morphogenesis.
24 citations
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January 2018 in “Development” This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.
This study with zebrafish found that inherited personality traits significantly influence the response to social stress, showing that individuals with certain coping styles were more vulnerable to health impairments, such as increased gut inflammation, than their social ranking alone would suggest.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that conditional deletion of Mof in mice resulted in severe defects in skin development, including compromised epidermal differentiation and hair growth, leading to perinatal lethality.
19 citations
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November 2016 in “Developmental Biology” 47 citations
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April 2000 in “Experimental Dermatology” This study identified a novel missense mutation in the hairless gene in a Polish family, which may contribute to congenital atrichia with papular lesions by affecting the gene's function.
41 citations
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April 2016 in “Journal of experimental botany” This research suggests that the barley protein RACB supports cell polarity functions rather than interfering with immunity, as it aids nucleus positioning during fungal attack rather than affecting early immune responses.
This study found that Ca²⁺ signaling and peptidylarginine deiminase enzymes play a crucial role in activating neural stem cells in response to injury in zebrafish, suggesting potential therapeutic targets for CNS injuries and cancer.
15 citations
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September 2013 in “Pharmaceutical Biology” This study found that Zizyphus jujuba fruit aqueous extract may reduce nephrotoxicity caused by ibuprofen in rats by lowering serum urea and creatinine and improving kidney antioxidant enzyme activities.
5 citations
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January 2021 in “Frontiers in Cell and Developmental Biology” This study found that elevated expression of the protein Zyxin in hair follicles is associated with androgenetic alopecia and suggests it may be targeted for therapy.
10 citations
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January 2020 in “Biomedicine & Pharmacotherapy” This study found that XiaoZhenFang (XZF) reduced skin toxicities caused by Erlotinib in a mouse model, likely through mechanisms involving inflammation and EGFR-related pathways.
31 citations
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October 2019 in “Genes & Diseases” This study identified significant gene expression differences in human basal cell carcinoma, including up-regulation of zinc finger encoding genes, which are not entirely reflected in current mouse models.
72 citations
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September 1975 in “Biology of Reproduction” This study found that zinc is primarily located in the tails of mature rat sperm, associated with -S-S-bonded structures, and suggests a possible similarity in zinc interactions between sperm keratin and hair proteins.
December 2025 in “Clinical Cosmetic and Investigational Dermatology” This study highlights the potential of ZDHHC17 methylation as a biomarker or therapeutic target in addressing skin aging, offering new insights into its molecular mechanisms.