TLDR Mutations in the ACTB gene cause Becker’s nevi and may lead to muscle issues in Becker’s nevus syndrome.
The study identified recurrent postzygotic mutations in the ACTB gene, specifically p.R147C and p.R147S, in 61% of Becker’s nevi cases, including one case of Becker’s nevus syndrome. These mutations were found exclusively in the pilar muscle lineage and were associated with increased Hedgehog (Hh) pathway signaling, which may disrupt hair follicle and muscle development. The findings suggested that these ACTB mutations underlie the development of Becker’s nevi and potentially contribute to the musculoskeletal abnormalities seen in Becker’s nevus syndrome.
113 citations
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September 2005 in “Journal of Investigative Dermatology” Applying a special compound can promote hair growth without harmful side effects.
September 2023 in “Curēus” A 21-year-old male has a benign skin condition called Becker's nevus, which he chose not to treat.
June 2023 in “British journal of dermatology/British journal of dermatology, Supplement” A girl with Becker naevus syndrome has a genetic variant in the ACTB gene related to her symptoms.
21 citations
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June 2010 in “Anais Brasileiros De Dermatologia” The document reports the first Brazilian case of a girl with Becker nevus syndrome, characterized by skin changes, breast underdevelopment, and scoliosis.
1 citations
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November 2023 in “Clinical, cosmetic and investigational dermatology” The long-pulse alexandrite laser is good for removing hair and treating skin problems like spots and veins.
7 citations
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January 2016 in “Case reports in pediatrics” A girl with Becker's nevus syndrome showed good improvement in breast development using spironolactone.
