Becker's Nevus Associated with Chromosomal Mosaicism and Congenital Adrenal Hyperplasia

    April 1994 in “ Journal of the American Academy of Dermatology ”
    Julien Lambert, Patrick J. Willems, Roger Abs, Bernadette Van Roy
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    TLDR High androgen levels and genetic factors likely cause Becker's nevus and related symptoms.
    The document described a 20-year-old woman with Becker's nevus, shoulder girdle hypotrophy, congenital adrenal hyperplasia with severe hirsutism, and chromosomal mosaicism. Elevated androgen levels led to increased hair growth, especially on the left shoulder and upper arm. Cyproterone acetate treatment reduced hirsutism but was less effective on the Becker's nevus. The study suggested that adrenal hyperplasia-induced androgen levels, combined with genetic mosaicism and hormonal susceptibility, contributed to the development of Becker's nevus, with cytogenetic abnormalities in fibroblasts indicating possible segmental skin dysplasia.
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