Congenital Atrichia and Hypotrichosis

The document from May 1, 2011, reviews congenital atrichia and hypotrichosis, highlighting the necessity for accurate diagnosis and classification of these hair disorders, which can be indicative of underlying genetic, metabolic, or syndromic conditions. It discusses the clinical and microscopic features of hereditary hair shaft disorders and the genes involved in hair follicle development. The paper focuses on genotrichosis, a type of genetic hair disorder, and provides a classification based on clinical features. It details specific conditions like Trichorhinophalangeal syndrome, Dubowitz syndrome, Hallermann-Streiff syndrome, ectodermal dysplasias, and others, including their clinical manifestations and genetic links. Additionally, the document mentions new syndromes and stresses the importance of a classification framework for congenital alopecia to facilitate accurate diagnoses and genetic testing. No funding or ethical approval was required for this review, and no competing interests were reported.