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    Glossary Wound Fibroblasts

    specialized cells that produce collagen to heal injured tissue

    Wound fibroblasts are specialized cells that play a crucial role in the healing process of injured tissue. When you get a cut or injury, these cells migrate to the wound site and produce collagen and other extracellular matrix components to help close the wound and form new tissue. They are essential for repairing and strengthening the damaged area.

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    1. Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses International Journal of Molecular Sciences · 2020 · 123 citations
    2. Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts Experimental Dermatology · 2020 · 35 citations
    3. 974 Single-cell analysis identifies heterogeneity of fibroblasts and myeloid-derived adipocytes in regenerating mouse skin wounds 2019 · 1 citations
    4. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing Cell stem cell · 2020 · 128 citations
    5. Hedgehog Signaling in Papillary Fibroblasts Is Essential for Hair Follicle Regeneration during Wound Healing Journal of Investigative Dermatology · 2021 · 5 citations
    6. Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing Development · 2016 · 87 citations
    7. GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration Experimental Dermatology · 2022 · 2 citations
    8. Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing Theranostics · 2018 · 49 citations
    9. Novel ECM Patch Combines Poly(vinyl alcohol), Human Fibroblast-Derived Matrix, and Mesenchymal Stem Cells for Advanced Wound Healing ACS Biomaterials Science & Engineering · 2020 · 28 citations
    10. Wound Healing Effect of Supercritical Carbon Dioxide Datura metel L. Leaves Extracts: An In Vitro Study of Anti-Inflammation, Cell Migration, MMP-2 Inhibition, and the Modulation of the Sonic Hedgehog Pathway in Human Fibroblasts Plants · 2023 · 6 citations
    11. Structure-guided PEGylated fibroblast growth factor 2 variants accelerate wound healing with improved stability 2020 · 1 citations
    12. Silk fibroin nanofibers-GelMA hydrogel composite loaded with embryonic fibroblasts: A strategy for enhanced wound healing Colloids and Surfaces B Biointerfaces · 2026
    13. Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration Clinical, Cosmetic and Investigational Dermatology · 2023
    14. 768 Dermal fibroblast expression of lef1 is critical to normal skin and hair development and regenerative wound healing in mice Journal of Investigative Dermatology · 2022
    15. Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds bioRxiv (Cold Spring Harbor Laboratory) · 2020
    16. 1424 Mapping the establishment of fibroblast heterogeneity during skin development and wound repair 2018
    17. Wound-healing effects of frozen-thawed allogeneic fibroblast sheet transplantation and xenogeneic fibroblast cell sheet transplantation cultured on a new substrate Tissue and Cell · 2025
    18. Effects Of Keratin-Gelatin And Basic Fibroblast Growth Factor-Gelatin Composite Film On Open Wound Healing In Dogs And Cats 2007
    19. Effects Of Keratin-Gelatin And Basic Fibroblast Growth Factor-Gelatin Composite Film On Open Wound Healing In Dogs And Cats Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · 2007
    20. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds Nature Communications · 2019 · 301 citations
    21. Fibroblasts and wound healing: an update Regenerative Medicine · 2018 · 146 citations
    22. Mechanotransduction unifies healthy non-diabetic wound healing over time by promoting a Cd14+/C1qa+ fibroblast subpopulation Journal of Investigative Dermatology · 2026
    23. Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma Frontiers in genetics · 2024
    24. Fibroblast state switching orchestrates dermal maturation and wound healing Molecular Systems Biology · 2018 · 126 citations
    25. Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing International Journal of Molecular Sciences · 2020 · 28 citations
    26. Rare Gli1+ perivascular fibroblasts promote skin wound repair bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    27. Integrated Single-Cell Analysis Reveals Spatially and Temporally Dynamic Heterogeneity in Fibroblast States during Wound Healing Journal of Investigative Dermatology · 2024 · 21 citations
    28. Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing International Journal of Molecular Sciences · 2024 · 16 citations
    29. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    30. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025 · 3 citations