Faculty Opinions Recommendation of FGF9 from Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding
October 2013
in “
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
”
TLDR FGF9 from certain T cells helps create new hair follicles during wound healing, which could potentially be used for hair loss treatments.
In 2013, a study conducted by Gay D et al. found that Fibroblast Growth Factor 9 (FGF9) from γδ T cells plays a crucial role in inducing hair follicle neogenesis during wound healing in mice. The study showed that FGF9 was significantly upregulated during late wound healing, and its overexpression resulted in an increase in wound-induced hair neogenesis (WIHN). The researchers found that FGF9 from γδ T cells triggered Wnt expression in dermal fibroblasts, which then secreted FGF20 through a feedback loop, leading to hair follicle neogenesis. However, the study also noted that humans have a lower number and restricted location of resident γδ T cells in the dermis, suggesting a poor regenerative capacity of human skin. The findings suggest potential clinical applications of FGF9 for hair loss treatments.
