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    Glossary Wnt ligands

    proteins that activate cell signaling for hair growth

    Wnt ligands are a group of proteins that play a crucial role in cell signaling, which is essential for various developmental processes, including hair growth and regeneration. They bind to specific receptors on the cell surface to activate pathways that control cell fate, proliferation, and migration.

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    1. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    2. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012 · 170 citations
    3. CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth Biochemical Journal · 2016 · 15 citations
    4. Faculty Opinions recommendation of Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    5. 693 Dermal papilla-derived Wnt ligands are required for adult hair follicle growth Journal of Investigative Dermatology · 2016
    6. 1448 Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration Journal of Investigative Dermatology · 2023
    7. ISID1448 – Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration 2023
    8. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proceedings of the National Academy of Sciences · 2013 · 176 citations
    9. β-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding [RETRACTED] Plastic and Reconstructive Surgery · 2018 · 13 citations
    10. 943 Temporal-spatial activation of Wnt-signaling within Type1 / Type 2 immunity during wound healing Journal of Investigative Dermatology · 2019
    11. Melatonin promotes hair regeneration by modulating the Wnt/β‐catenin signalling pathway Cell proliferation · 2024
    12. Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    13. Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin International Journal of Molecular Sciences · 2025
    14. Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin 2024
    15. LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes Journal of Investigative Dermatology · 2023
    16. Embryonic-like regenerative phenomenon: wound-induced hair follicle neogenesis Regenerative Medicine · 2018 · 10 citations
    17. 362 Not just a cell marker: DPP4 modulates regeneration of hair follicles in large wounds Journal of Investigative Dermatology · 2021
    18. A cell polarity protein, aPKCλ, is essential for maintaining hair follicle stem cell quiescence and hair follicle regeneration Journal of Dermatological Science · 2016
    19. Decision letter: A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning 2017
    20. TNF superfamily in skin appendage development Cytokine & growth factor reviews · 2008 · 86 citations
    21. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development 2012 · 48 citations
    22. 859 Building a functional niche for hair follicle stem cells Journal of Investigative Dermatology · 2017
    23. Hedgehog-Wnt Interactions during Pathologic Epithelial Bud Development and Skin Tumorigenesis. Deep Blue (University of Michigan) · 2008
    24. Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury Nature Communications · 2021 · 57 citations
    25. Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes 2013 · 13 citations
    26. Pigmentation of regenerated hairs after wounding Journal of Dermatological Science · 2016 · 16 citations
    27. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    28. Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo Journal of Dermatological Science · 2016 · 45 citations
    29. Hairy Math: Addition of Wnt-3a to Multiply Bulge Cells Journal of Investigative Dermatology · 2015
    30. Skin transcriptome reveals the dynamic changes in the Wnt pathway during integument morphogenesis of chick embryos PLoS ONE · 2018 · 23 citations