77 citations
,
August 1986 in “Archives of Dermatology” This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.
21 citations
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January 2009 in “Indian journal of dermatology, venereology, and leprology” Vitamin B12, folate, ferritin, and iron levels are not linked to alopecia areata.
20 citations
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July 1990 in “Clinical and experimental dermatology” In this study, women treated for androgen-dependent alopecia with CPA EE2 therapy experienced significant decreases in serum vitamin B12, hemoglobin, and hematocrit levels after six months.
17 citations
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December 1951 in “Experimental biology and medicine” In this study of immature male albino rats on a vitamin B12-deficient diet, vitamin B12 supplementation improved body, hair, and thymus growth more effectively than aureomycin when countering the negative effects of cortisone.
16 citations
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January 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that premature hair graying is strongly associated with a family history, Vitamin B12 deficiency, and hypothyroidism, with onset as early as 5 years in patients in Gurugram, India.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
16 citations
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January 2008 in “Acta dermato-venereologica” Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.
13 citations
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May 2012 in “Cutaneous and ocular toxicology” In this study, researchers found no significant differences in vitamin B12, folate, and homocysteine metabolism between patients with alopecia areata and controls, suggesting no association with vitamin B12 deficiency.
12 citations
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October 1952 in “Experimental biology and medicine” This study found that in young male rats, cortisone acetate inhibited body growth and caused alopecia, which vitamin B12 and aureomycin largely counteracted, especially when combined.
11 citations
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August 1986 in “Archives of Dermatology” This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.
8 citations
,
January 2007 in “Hair transplant forum international” This abstract reviews recent findings on the biology of isolated micrografts in hair restoration, emphasizing factors that enhance micrograft viability, but it does not report new experimental results.
5 citations
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August 2015 in “Sultan Qaboos University medical journal” This case report highlights an atypical presentation of vitamin B12 deficiency in a 28-year-old man with reversible symptoms including localized hand hyperpigmentation and megaloblastic anemia, resolved after B12 supplementation.
4 citations
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March 2020 in “JAAD Case Reports” This case report describes a 47-year-old male with rare total melanonychia linked to vitamin B12 deficiency, whose nail discoloration and constitutional symptoms improved following vitamin B12 supplementation.
4 citations
,
January 2011 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study demonstrated that vitamin B12 may promote hair growth in vitro by modulating intracellular signaling in the wnt-pathway, suggesting potential benefits for micrograft transplantation.
2 citations
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October 2016 in “Nutrition in clinical practice” This case report describes a rare instance of reversible melasma-like hyperpigmentation linked to vitamin B12 deficiency due to pernicious anemia, and explores possible mechanisms for this association.
2 citations
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December 2015 in “Journal of dermatology research and therapy” This study compared serum zinc, vitamin B12, folic acid levels, iron metabolism, and thyroid function between chronic telogen effluvium patients and healthy controls, but it reports no specific clinical results.
2 citations
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September 2012 in “Turk Dermatoloji Dergisi” Low levels of ferritin and vitamin B12 are common in women with telogen effluvium, but the link between nutrient deficiencies and the condition is not clear.
1 citations
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April 2021 in “International Journal of Research in Dermatology” This study found low serum ferritin and vitamin B12 levels in a significant portion of women with chronic telogen effluvium, while vitamin D deficiency was less common.
1 citations
,
January 2021 in “International journal of pharmaceutical research” This study found that reduced levels of ferritin, TSH, and hemoglobin in young women and lower TSH, vitamin B12, and vitamin D in older women are associated with chronic diffuse hair loss.
1 citations
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January 2013 in “Nasza Dermatologia Online” This case report describes reversible hypopigmentation of hair in a child due to vitamin B12 deficiency, which improved after vitamin B12 supplementation.
1 citations
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September 2007 in “Neuromuscular disorders” This study suggests that long-term treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may benefit children with SMA types II and III by improving muscle strength and function without significant adverse effects.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This single patient case report observed that Vidarikandadi Kala Basti, an Ayurvedic Panchakarma procedure, was linked to modest improvements in Vitamin B12 levels and clinical symptoms, but larger studies are needed to determine its potential role in managing Vitamin B12 deficiency.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this case report, a 22-year-old male with Vitamin B12 deficiency showed improved clinical symptoms and a modest rise in Vitamin B12 levels after undergoing classical Panchakarma therapy, though the authors emphasize that causality remains undetermined and further research is necessary.
June 2026 in “International Journal Of Ayurvedic And Herbal Medicine” This case report described the use of Vidarikandadi Kala Basti, a Panchakarma procedure, which was associated with improved symptoms and a modest Vitamin B12 increase in a patient with deficiency; however, the authors noted that causality cannot be established, and further controlled studies are needed.
October 2025 in “International Journal For Multidisciplinary Research” This study describes a case where a patient with Vitamin B12 deficiency symptoms achieved increased serum B12 levels and symptom relief through treatment with Amyron syrup and Amlycure DS capsules, rather than traditional B12 supplements.
July 2025 in “Humanitarian and Natural Sciences Journal” In this study, women with hair loss were found to have significantly lower levels of vitamin D and ferritin compared to healthy controls, suggesting that these micronutrients may play a role in hair health and could be important in nutritional assessments for hair loss conditions.
June 2025 in “International Journal of Science and Research (IJSR)” This study found that among 100 females with chronic telogen effluvium, approximately two-thirds had low levels of serum ferritin and vitamin D, while vitamin B12 deficiency was observed in only about one-third of the participants.
January 2025 in “The International Journal of Gastroenterology and Hepatology Diseases” This study explored how vitamin B12 is essential for hair growth and nervous system health, highlighting that factors causing its malabsorption, like gastric issues and smoking, can lead to optic neuropathy and hair loss.
October 2024 in “INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH” This study found that trichoscopy can effectively identify specific patterns associated with Vitamin B12, Vitamin D3, and serum ferritin deficiencies in patients with Telogen Effluvium, offering a non-invasive alternative to blood tests for early diagnosis and management.
August 2024 in “Journal of Cosmetic Dermatology” This study investigates differences in nutritional status, vitamin, and mineral levels between individuals with telogen effluvium and a control group, aiming to understand the nutritional factors involved in this condition.